Recep Tayyip Erdogan University, Training and Research Hospital, Chest Disease, Rize, Turkey.
Recep Tayyip Erdogan University, Training and Research Hospital, Medical Biochemistry, Rize, Turkey.
Can Respir J. 2022 Jan 29;2022:8340450. doi: 10.1155/2022/8340450. eCollection 2022.
Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls.
Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (-SH); TT: total thiol (-SH + SS); SS: disulfide (-SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. . Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compared with healthy controls. A positive correlation between the total airway disease score and IMA levels was present. Our findings revealed that native thiol levels, which constitute a part of the antioxidant defense system, are increased in patients with stable bronchiectasis.
巯基是含硫氢基的有机化合物，在预防细胞氧化应激方面具有重要作用。本研究比较了处于稳定期的支气管扩张症患者与健康对照者的血液氧化应激标志物水平。
本研究纳入了 77 名（49 名稳定期支气管扩张症患者/28 名健康对照者）在胸部疾病诊所接受随访的患者。检测了稳定期支气管扩张症组和对照组的外周血巯基-二硫键参数（NT：天然巯基（-SH）；TT：总巯基（-SH+SS）；SS：二硫键（-SS）；SS-SH：二硫键/天然巯基指数；SS-TT：二硫化物/总巯基指数；SH-TT：天然巯基/总巯基指数）和缺血修饰白蛋白（IMA）水平。采用新型自动化检测方法评估巯基-二硫键平衡。与健康对照组相比，稳定期支气管扩张症患者的血液天然巯基水平显著升高。总气道疾病评分与 IMA 水平呈正相关。我们的研究结果表明，稳定期支气管扩张症患者的天然巯基水平升高，而天然巯基是抗氧化防御系统的一部分。
