State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
J Org Chem. 2021 Jan 15;86(2):2017-2022. doi: 10.1021/acs.joc.0c02727. Epub 2021 Jan 4.
Illihenin A (), a novel sesquiterpenoid, was isolated from the roots of . The structure was determined by spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction. Compound represents a class of novel 5/7/6 tricyclic sesquiterpenoids featuring a rare cage-like tricyclo[6.2.2.0]dodecane core. A plausible biosynthetic pathway of by rearrangement of -cedrane is proposed. Additionally, showed potent antiviral activity against coxsackievirus B3 with an IC value of 2.87 μM.
异落叶松脂素 A（Illihenin A），一种新型的倍半萜，从 的根部中分离得到。结构通过光谱分析、ECD 计算和单晶 X 射线衍射确定。化合物 代表了一类新型的 5/7/6 三环倍半萜，具有罕见的笼状三环[6.2.2.0]十二烷核心。提出了通过 -cedrane 重排生成 的可能生物合成途径。此外， 对柯萨奇病毒 B3 表现出强烈的抗病毒活性，IC 值为 2.87 μM。
