八角属植物根中的二萜和倍半萜。
Diterpenoids and sesquiterpenoids from the roots of Illicium majus.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
出版信息
J Nat Prod. 2013 Oct 25;76(10):1976-83. doi: 10.1021/np400638r. Epub 2013 Sep 26.
Five new diterpenoids (1-5), five new sesquiterpenoids (6-10), and three known compounds (11-13) were isolated from the roots of Illicium majus. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was assigned by X-ray crystallography, whereas those of the 1,2-diol moieties in 3 and 4 were determined using Snatzke's method. The abietane acids 1, 2, 11, 12, and 13 displayed antiviral activity against the Coxsackie B3 virus, with IC50 values of 3.3-51.7 μM/mL.
从八角属植物的根部分离得到五个新的二萜类化合物（1-5）、五个新的倍半萜类化合物（6-10）和三个已知化合物（11-13）。通过广泛的光谱分析阐明了它们的结构。通过 X 射线晶体学确定了 1 的绝对构型，而 3 和 4 中 1,2-二醇部分的构型则使用 Snatzke 法确定。阿比烷酸 1、2、11、12 和 13 对柯萨奇 B3 病毒具有抗病毒活性，IC50 值为 3.3-51.7 μM/mL。
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