Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Curr Med Chem. 2021;28(22):4296-4320. doi: 10.2174/0929867328666210104104938.
Major Depressive Disorder(MDD) and its frequent partial response to antidepressants are a major health concern and therefore an important focus of research. Despite the efforts, MDD pathogenesis and the mechanisms of antidepressant action are only partially understood. In the last few years, the need of rethinking the classification of depressive disorders and psychiatric disorders, in general, has been suggested, in order to provide a nosology that reflects more closely the biological background associated with disease pathogenesis and its role/significance in treatment. The classification proposed by the National Institute of Mental Health (NIMH), namely the research domain criteria (RDoC), may represent a key framework to guide research in this direction.
A literature search was performed on PubMed and Google Scholar databases in order to retrieve data regarding Antidepressants effects on specific RDoC constructs. Further, the targets of drugs of interest were identified through the Drug bank database, and their possible function within RDoC constructs was discussed.
In this review, we summarize and discuss the significance of the results of pre-clinical and clinical studies investigating specific RDoC paradigms relevant to depressive phenotypes and antidepressant effects.
The RDoC framework may facilitate a more specific use of antidepressants based on the individual's spectrum of symptoms and the development of new compounds that target specific depressive symptoms.
重度抑郁症（MDD）及其对抗抑郁药的常见部分反应是一个主要的健康关注点，因此也是研究的重要重点。尽管付出了努力，但 MDD 的发病机制和抗抑郁药作用机制仍仅部分了解。在过去的几年中，有人建议重新思考抑郁障碍和精神障碍的分类，以便提供更能反映与疾病发病机制相关的生物学背景的分类法，以及它在治疗中的作用/意义。美国国立卫生研究院（NIMH）提出的分类，即研究领域标准（RDoC），可能代表了指导这一方向研究的关键框架。
在 PubMed 和 Google Scholar 数据库上进行了文献检索，以检索有关抗抑郁药对特定 RDoC 结构影响的数据。此外，通过 Drug bank 数据库确定了感兴趣药物的靶标，并讨论了它们在 RDoC 结构中的可能功能。
在这篇综述中，我们总结并讨论了调查与抑郁表型和抗抑郁作用相关的特定 RDoC 范式的临床前和临床研究结果的意义。
RDoC 框架可以根据个体的症状谱和针对特定抑郁症状的新化合物的开发，更具体地使用抗抑郁药。
