Departments of Hematology.
The First People's Hospital Wuyi County, Jinhua, Zhejiang, China.
J Pediatr Hematol Oncol. 2022 Apr 1;44(3):e616-e622. doi: 10.1097/MPH.0000000000002173.
The aim of this study was to explore the potential association the cytosolic serine hydroxy methyltransferase (SHMT1) rs1979277 polymorphism and the risk of acute lymphoblastic leukemia (ALL).
Comprehensive search of Web of Science, PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), and China Biomedical Literature Database electronic database, was performed to identify relevant studies published throughout April 30, 2019. The heterogeneity in the study was judged by the I2 and P-values, and then the random ratio or fixed effect was used to calculate the pooled odds ratios (OR) based on the presence or absence of heterogeneity. Sensitivity analysis is used to estimate the impact of individual studies on aggregate estimates. The publication bias of the study was tested using a funnel plot and an Egger regression.
Nine studies with a total of 6492 participants (2971 patients; 3521 controls) were included in this meta-analysis. We found that SHMT1 rs1979277 polymorphism was not significantly associated with the risk of ALL in the dominant model: CC versus CT+TT (OR=0.84, 95% confidence interval [CI]: 0.46-1.54, P=0.57), recessive model: CC+CT versus TT (OR=0.81, 95% CI: 0.44-1.49, P=0.50) and allele model: C versus T (OR=0.84, 95% CI: 0.52-1.35, P=0.48). In subgroup analysis by ethnicity, no significant association were found in dominant, recessive and allele models in both Caucasian and Asian populations.
Our study indicated that the SHMT1 rs1979277 polymorphism was not associated with the risk of susceptibility to ALL.
本研究旨在探讨细胞质丝氨酸羟甲基转移酶（SHMT1）rs1979277 多态性与急性淋巴细胞白血病（ALL）风险之间的潜在关联。
通过 Web of Science、PubMed、Ovid、Cochrane Library、Embase、中国知网（CNKI）和中国生物医学文献数据库电子数据库，全面检索截至 2019 年 4 月 30 日发表的相关研究。采用 I2 和 P 值判断研究间的异质性，然后根据是否存在异质性，采用随机比或固定效应计算汇总优势比（OR）。采用敏感性分析估计单个研究对汇总估计的影响。采用漏斗图和 Egger 回归检验研究的发表偏倚。
本荟萃分析纳入了 9 项研究，共 6492 名参与者（2971 例患者；3521 例对照）。我们发现，SHMT1 rs1979277 多态性与 ALL 的风险在显性模型（CC 与 CT+TT 相比：OR=0.84，95%置信区间 [CI]：0.46-1.54，P=0.57）、隐性模型（CC+CT 与 TT 相比：OR=0.81，95% CI：0.44-1.49，P=0.50）和等位基因模型（C 与 T 相比：OR=0.84，95% CI：0.52-1.35，P=0.48）中无显著相关性。在按种族进行的亚组分析中，在白人和亚洲人群中，显性、隐性和等位基因模型均未发现显著相关性。
本研究表明，SHMT1 rs1979277 多态性与 ALL 易感性风险无关。
