VanLandingham K E, Marsteller H B, Ross G W, Hayden F G
Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908.
JAMA. 1988 Feb 19;259(7):1051-3.
Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis.
阿昔洛韦钠是治疗单纯疱疹性脑炎的首选药物。我们对一名免疫功能正常的患者进行了为期十天的静脉注射阿昔洛韦钠治疗，按照推荐剂量每八小时10mg/kg，用于治疗临床表现明显的单纯疱疹性脑炎。病情显著改善后，在完成阿昔洛韦治疗四天后他的病情恶化。随后的脑活检标本显示为对阿昔洛韦敏感的1型单纯疱疹病毒。治疗单纯疱疹性脑炎时应考虑延长阿昔洛韦治疗疗程（14至21天）。
