Barthez M A, Billard C, Santini J J, Ruchoux M M, Grangeponte M C
Neuropediatrics. 1987 Feb;18(1):3-7. doi: 10.1055/s-2008-1052425.
This report describes a child with herpes simplex virus (HSV) encephalitis who improved dramatically while being treated with acyclovir but subsequently had neurological deterioration and died. A severe necrotizing process was present in the brain at autopsy but there were no focal areas of demyelination and poor inflammatory response. HSV was not cultured from brain biopsy during relapse or autopsy. Fourteen previous cases of relapsing herpes encephalitis are reviewed and treatment regime and mechanisms of relapse are discussed.
本报告描述了一名患有单纯疱疹病毒（HSV）脑炎的儿童，该患儿在接受阿昔洛韦治疗时病情显著改善，但随后出现神经功能恶化并死亡。尸检时脑部存在严重的坏死过程，但没有脱髓鞘的局灶性区域且炎症反应较弱。在病情复发或尸检时，脑活检未培养出HSV。回顾了之前14例复发性疱疹性脑炎的病例，并讨论了治疗方案和复发机制。
