Moghimi Minoosh, Moghtader Amirhossein, Jozpanahi Manijeh, Khodadadi Kasra, Jafarzade Mohammad, Abbaspour Zahra
Department of Internal Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Infectious Disease, Zanjan University of Medical Sciences, Zanjan, Iran.
Respir Med Case Rep. 2021;32:101335. doi: 10.1016/j.rmcr.2020.101335. Epub 2020 Dec 31.
Recent studies have focused on the incidence rate and pattern of meningoencephalitis in the coronavirus disease 2019 (COVID-19).
This study aims to shed more light on the CSF pattern and clinical characteristics of meningoencephalitis COVID-19 patients in Zanjan, Iran.
Nine cases of laboratory and imaging confirmed COVID-19 were admitted to Valiasr Hospitals in Zanjan, Iran. Data were collected from May 20, 2020 to June 20, 2020.
All the nine patients had positive RT-PCR COVID-19 and Pulmonary involvement who underwent Lumbar puncture and analysis, but despite neurological symptoms, the RT-PCR of CSF for COVID-19 was negative.
Although we did not have any cases of positive RT-PCR for COVID-19 in lumbar puncture specimens, the justification of neurological symptoms in patients can be the transient presence of the virus in the CSF, and inflammation or autoimmune response caused by the virus, so more studies are needed to determine the cause of neurogenic symptoms.
近期研究聚焦于2019冠状病毒病（COVID-19）中脑膜脑炎的发病率和模式。
本研究旨在进一步阐明伊朗赞詹COVID-19脑膜脑炎患者的脑脊液特征和临床特点。
9例经实验室和影像学确诊的COVID-19患者入住伊朗赞詹的瓦利阿斯尔医院。数据收集于2020年5月20日至2020年6月20日。
所有9例患者RT-PCR检测COVID-19呈阳性且有肺部受累，均接受了腰椎穿刺及分析，但尽管有神经症状，脑脊液COVID-19的RT-PCR检测为阴性。
尽管我们的腰椎穿刺标本中没有COVID-19的RT-PCR阳性病例，但患者神经症状的原因可能是病毒在脑脊液中的短暂存在，以及病毒引起的炎症或自身免疫反应，因此需要更多研究来确定神经源性症状的原因。
