Department of Anatomy, Co-Innovation Center of Neuroregeneration, Medical School, Nantong University, Nantong, Jiangsu 226001, P.R. China.
Department of Clinical Medicine, Faculty of Medicine, Xinglin College, Nantong University, Nantong, Jiangsu 226008, P.R. China.
Mol Med Rep. 2021 Mar;23(3). doi: 10.3892/mmr.2020.11818. Epub 2021 Jan 5.
Brain 4 (Brn4) is a transcription factor belonging to the POU3 family, and it is important for the embryonic development of the neural tube, inner ear and pancreas. In addition, it serves a crucial role in neural stem cell differentiation and reprogramming. The present review aimed to summarize the chromosomal location, species homology, protein molecular structure and tissue distribution of Brn4, in addition to its biological processes, with the aim of providing a reference of its structure and function for further studies, and its potential use as a gene therapy target.
脑 4 (Brn4) 是一种转录因子，属于 POU3 家族，对于神经管、内耳和胰腺的胚胎发育非常重要。此外，它在神经干细胞分化和重编程中起着关键作用。本综述旨在总结 Brn4 的染色体位置、种同源性、蛋白质分子结构和组织分布，以及其生物学过程，为进一步研究提供其结构和功能的参考，并为基因治疗的潜在靶点提供参考。
