State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Mol Med Rep. 2021 Mar;23(3). doi: 10.3892/mmr.2020.11806. Epub 2021 Jan 5.
The periodontium is a highly dynamic microenvironment constantly adapting to changing external conditions. In the processes of periodontal tissue formation and remodeling, certain molecules may serve an essential role in maintaining periodontal homeostasis. Wnt family member 5a (Wnt5a), as a member of the Wnt family, has been identified to have extensive biological roles in development and disease, predominantly through the non‑canonical Wnt signaling pathway or through interplay with the canonical Wnt signaling pathway. An increasing number of studies has also demonstrated that it serves crucial roles in periodontal tissues. Wnt5a participates in the development of periodontal tissues, maintains a non‑mineralized state of periodontal ligament, and regulates bone homeostasis. In addition, Wnt5a is involved in the pathogenesis of periodontitis. Recently, it has been shown to serve a positive role in the regeneration of integrated periodontal complex. The present review article focuses on recent research studies of Wnt5a and its functions in development, maintenance, and pathological disorders of periodontal tissues, as well as its potential effect on periodontal regeneration.
牙周组织是一个高度动态的微环境，不断适应外部环境的变化。在牙周组织形成和重塑的过程中，某些分子可能在维持牙周平衡中发挥重要作用。Wnt 家族成员 5a（Wnt5a）作为 Wnt 家族的一员，在发育和疾病中具有广泛的生物学作用，主要通过非经典 Wnt 信号通路或与经典 Wnt 信号通路相互作用。越来越多的研究还表明，它在牙周组织中起着至关重要的作用。Wnt5a 参与牙周组织的发育，维持牙周韧带的非矿化状态，并调节骨平衡。此外，Wnt5a 还参与牙周炎的发病机制。最近的研究表明，它在整合性牙周复合体的再生中发挥积极作用。本文综述了 Wnt5a 的最新研究进展及其在牙周组织发育、维持和病理性紊乱中的功能，以及其对牙周再生的潜在影响。
