Jeong Hun Jin, Hoang Lan Anh P, Chen Neeve, Zhu Elen, Wang Albert, Chen Bozhi, Wang Emma Y, Ricupero Christopher L, Lee Chang H
College of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Bioact Mater. 2024 Nov 25;45:246-256. doi: 10.1016/j.bioactmat.2024.11.030. eCollection 2025 Mar.
The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meniscus-bone have been extensively researched as regenerative targets. Similarly, extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium. However, the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected. This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system. It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities. The remaining challenges, future perspectives, and considerations for the clinical translation of bioactive scaffolds are also discussed.
软组织与硬组织之间的界面由细胞类型和基质组成的梯度变化构成，这些变化经过优化设计，以实现适当的负荷传递和损伤保护。在肌肉骨骼系统中，肌腱-骨、韧带-骨和半月板-骨处的软组织-硬组织界面作为再生靶点已得到广泛研究。同样，人们也进行了大量研究工作来引导牙周组织中多组织复合体的再生。然而，牙齿和颅面系统中的其他软组织-硬组织界面在一定程度上被忽视了。本综述讨论了为牙齿和颅面系统中的软组织-硬组织界面开发再生策略的临床意义。它还讨论了该领域的研究进展，重点是使用具有空间控制生物活性的3D支架的生物工程方法。还讨论了生物活性支架临床转化中 remaining challenges、未来前景和注意事项。（注：这里“remaining challenges”直接保留英文，因为不清楚其确切含义，如果是“剩余挑战”之类的意思，可根据实际调整）
