Department of Ultrasonic Diagnosis, Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Scand J Gastroenterol. 2021 Mar;56(3):252-258. doi: 10.1080/00365521.2020.1868568. Epub 2021 Jan 5.
The relationship between hepatitis B virus (HBV) and pancreatic cancer has been controversial for years, but more recently new information on this relationship has been updated Therefore, we performed a meta-analysis to provide summary estimates of the risk of pancreatic cancer associated with HBV infection.
A systematic literature search on HBV and pancreatic cancer in English was performed in Pubmed, Cochrane library and Embase up to July 2020. Pooled rate ratios (RRs) and 95% confidence intervals (CIs) were calculated by the random-effects model. Stata software version 15.1 was used to perform this meta-analysis of the 17 studies considered to be eligible.
17 studies including 7 case-control and 10 cohort studies met the selection criteria. Begg's and Egger's test results indicated that there was no publication bias. Individuals with Hepatitis B surface antigen (HBsAg) or HBV DNA seropositivity had a significantly increased risk of pancreatic cancer showing an RR (95% CI) of 1.39 (1.19, 1.63). Similar conclusions were drawn from the results of the subgroup analysis (subgroup by study design, population, sex ratio) except when subgrouped by patient's region: the RR and 95% CI in Europe and Oceania were 1.44 (0.88, 2.34) and 1.47(0.38, 5.71) respectively.
The findings of this meta-analysis suggest that HBV infections may increase the risk of pancreatic cancer under most conditions, while there remains some doubt when comparison is made between European and Oceania patients.
乙型肝炎病毒（HBV）与胰腺癌之间的关系多年来一直存在争议，但最近有关这种关系的新信息已经更新。因此，我们进行了荟萃分析，以提供与 HBV 感染相关的胰腺癌风险的综合估计。
我们在 Pubmed、Cochrane 图书馆和 Embase 中以英文对 HBV 和胰腺癌进行了系统的文献检索，检索时间截至 2020 年 7 月。使用随机效应模型计算汇总率比（RR）和 95%置信区间（CI）。使用 Stata 软件版本 15.1 对 17 项被认为符合条件的研究进行了荟萃分析。
17 项研究包括 7 项病例对照研究和 10 项队列研究符合选择标准。Begg 和 Egger 检验结果表明没有发表偏倚。乙型肝炎表面抗原（HBsAg）或 HBV DNA 血清阳性的个体患胰腺癌的风险显著增加，RR（95%CI）为 1.39（1.19，1.63）。亚组分析（按研究设计、人群、性别比亚组）的结果得出了类似的结论，但按患者所在地区进行亚组分析时除外：欧洲和大洋洲的 RR 和 95%CI 分别为 1.44（0.88，2.34）和 1.47（0.38，5.71）。
这项荟萃分析的结果表明，在大多数情况下，HBV 感染可能会增加患胰腺癌的风险，而在比较欧洲和大洋洲患者时仍存在一些疑问。
