Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Clin Respir J. 2021 May;15(5):472-481. doi: 10.1111/crj.13323. Epub 2021 Jan 28.
The study aimed to explore the effect of reminiscence therapy-based care program (RTCP) on anxiety, depression, quality of life (QoL), and survival profiles in post-operational non-small cell lung cancer (NSCLC) patients.
In this randomized, controlled study, a total of 192 newly diagnosed post-operational NSCLC patients were randomly assigned to control care program (CCP) group (N = 96) or RTCP group (N = 96), and both groups experienced 12-month intervention and 36-month follow-up without intervention. Hospital Anxiety and Depression Scale (HADS) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) were evaluated at baseline (M0), month (M)3, M6, and M12.
Reduced HADS-anxiety score at M6 and M12, anxiety rate at M12, and anxiety severity at M6 and M12 were observed in RTCP group compared with CCP group. Additionally, HADS-depression score was decreased at M6 and M12, while both depression rate and severity were of no difference at each time point between two groups. Furthermore, QLQ-C30 global health status score at M6 and M12, QLQ-C30 functions score at M12 were increased, while QLQ-C30 symptoms score was of no difference at each time point in RTCP group compared with CCP group. Regarding survival profiles, Kaplan-Meier curves indicated that disease-free survival and overall survival were of no difference between two groups, further multivariate Cox's proportional hazard regression analysis also observed the same trends.
RTCP effectively relieves anxiety and depression, improves QoL, but did not prolong survival, suggesting its value as a non-pharmacological approach for post-operational NSCLC management.
本研究旨在探讨基于回忆疗法的护理方案（RTCP）对术后非小细胞肺癌（NSCLC）患者焦虑、抑郁、生活质量（QoL）和生存状况的影响。
在这项随机对照研究中，共有 192 名新诊断的术后 NSCLC 患者被随机分配至对照组（CCP 组，n=96）或 RTCP 组（n=96），两组均接受 12 个月的干预和 36 个月的无干预随访。在基线（M0）、第 3 个月（M3）、第 6 个月（M6）和第 12 个月（M12）时，使用医院焦虑抑郁量表（HADS）和欧洲癌症研究与治疗组织生活质量问卷（QLQ-C30）进行评估。
与 CCP 组相比，RTCP 组在 M6 和 M12 时 HADS 焦虑评分降低，M12 时焦虑发生率降低，M6 和 M12 时焦虑严重程度降低。此外，M6 和 M12 时 HADS 抑郁评分降低，而两组在各时间点的抑郁发生率和严重程度均无差异。此外，与 CCP 组相比，RTCP 组在 M6 和 M12 时 QLQ-C30 总体健康状况评分增加，M12 时 QLQ-C30 功能评分增加，而各时间点的 QLQ-C30 症状评分无差异。关于生存状况，Kaplan-Meier 曲线表明两组无疾病生存和总生存无差异，进一步的多变量 Cox 比例风险回归分析也观察到相同趋势。
RTCP 能有效缓解焦虑和抑郁，提高 QoL，但不能延长生存时间，提示其作为术后 NSCLC 管理的非药物治疗方法具有一定价值。
