Department of Operating Room, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Department of Ultrasonography, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Clin Res Hepatol Gastroenterol. 2021 May;45(3):101546. doi: 10.1016/j.clinre.2020.09.007. Epub 2020 Oct 24.
This study aimed to investigate the effect of reminiscence therapy-involved care (RTC) program on anxiety, depression, quality of life and survival in colorectal cancer (CRC) patients.
There were 210 post-resection CRC patients recruited and randomly received RTC (N = 105) or control care (CC) (N = 105) for 12 months. Their anxiety, depression and quality of life were assessed using Hospital Anxiety and Depression Scale (HADS) and European Organization for Research and Treatment of Cancer quality of life Questionnaire-Core 30 (QLQ-C30) at baseline (Month (M) 0), M3, M6 and M12. Patients were further followed up to 36 months, followed by the overall survival (OS) calculation.
HADS-anxiety score was decreased at M6/M12 and anxiety patients' percentage was reduced at M12 in RTC group compared with CC group; HADS-depression score was lower at M6/M12, while depression patients' percentage was similar at each time point in RTC group compared with CC group; QLQ-C30 global health status score and QLQ-C30 functions score were increased at M6/M12, while QLQ-C30 symptoms score was similar at each time point in RTC group compared with CC group. Further sub-group analysis displayed that: in patients with age ≥65 years, patients with pathological grade G2 and patients with TNM stage Ⅱ-Ⅲ, RTC showed more remarkable effect. Additionally, OS showed a higher trend in RTC group compared with CC group, but without statistical difference.
RTC contributes to anxiety and depression alleviations as well as the quality of life improvement in CRC patients.
本研究旨在探讨回忆疗法参与式护理（RTC）方案对结直肠癌（CRC）患者焦虑、抑郁、生活质量和生存的影响。
共招募了 210 例结直肠切除术后的 CRC 患者，随机分为 RTC 组（N=105）或对照组（CC）（N=105），接受为期 12 个月的 RTC 或 CC。在基线（M0）、M3、M6 和 M12 时使用医院焦虑抑郁量表（HADS）和欧洲癌症研究与治疗组织生活质量问卷核心 30 项（QLQ-C30）评估患者的焦虑、抑郁和生活质量。进一步随访至 36 个月，计算总生存期（OS）。
与 CC 组相比，RTC 组在 M6/M12 时 HADS 焦虑评分降低，M12 时焦虑患者比例减少；RTC 组在 M6/M12 时 HADS 抑郁评分较低，而 M6/M12 时抑郁患者比例与 CC 组相似；RTC 组在 M6/M12 时 QLQ-C30 总体健康状况评分和功能评分增加，而 M6/M12 时症状评分与 CC 组相似。进一步的亚组分析显示：在年龄≥65 岁、病理分级 G2 和 TNM 分期Ⅱ-Ⅲ的患者中，RTC 显示出更显著的效果。此外，RTC 组的 OS 有较高的趋势，但与 CC 组相比无统计学差异。
RTC 有助于缓解 CRC 患者的焦虑和抑郁，改善生活质量。
