The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., 620014 Yekaterinburg, Russia.
Central Research Laboratory, The Ural State Medical University, 17 Klyuchevskaya Str., 620109 Yekaterinburg, Russia.
Int J Mol Sci. 2021 Jan 3;22(1):416. doi: 10.3390/ijms22010416.
Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m in a "nose only" inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all.
大鼠在“鼻only”吸入装置中以 2.4 ± 0.4 µg/m 的浓度暴露于氧化镍纳米气溶胶中，每次 4 小时，每周 5 次，总暴露周期为 2 周至 6 个月。基于评估的大多数影响，这种暴露可能被认为接近 LOAEL（最低观察到的不良效应水平），甚至接近 NOAEL（无观察到的不良效应水平）。同时，实验在暴露的第一周就揭示了遗传毒性和过敏效应，表明这些效应可能根本没有阈值。
