Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Int J Mol Sci. 2021 Jan 3;22(1):419. doi: 10.3390/ijms22010419.
Gender differences in pulmonary inflammation have been well documented. Although low molecular mass hyaluronan (LMMHA) is known to trigger pulmonary lung inflammation, sex differences in susceptibility to LMMHA are still unknown. In this study, we test the hypothesis that mice may display sex-specific differences after LMMHA administration. After LMMHA administration, male mice have higher neutrophil, cytokine, and chemokine counts compared to that of their female counterparts. Additionally, Ovariectomized (OVX) mice show greater LMMHA-induced inflammation compared to that of mice with intact ovaries. Injections of OVX mice with 17β-estradiol can decrease inflammatory responses in the OVX mice. These results show that ovarian hormones regulate LMMHA induced lung inflammation.
性别差异与肺部炎症已有大量记载。尽管已知低分子质量透明质酸（LMMHA）可引发肺部炎症，但对于其引发的炎症易感性是否存在性别差异仍不清楚。在这项研究中，我们验证了一个假设，即给予 LMMHA 后，雄性小鼠可能表现出性别特异性差异。与雌性小鼠相比，给予 LMMHA 后雄性小鼠的中性粒细胞、细胞因子和趋化因子计数更高。此外，与具有完整卵巢的小鼠相比，去卵巢（OVX）小鼠表现出更强的 LMMHA 诱导炎症。向 OVX 小鼠注射 17β-雌二醇可降低 OVX 小鼠的炎症反应。这些结果表明，卵巢激素调节 LMMHA 诱导的肺部炎症。
