Gur David, Chitlaru Theodor, Mamroud Emanuelle, Zauberman Ayelet
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, 24 Reuven Lerer, Ness Ziona 74010001, Israel.
Antibiotics (Basel). 2021 Jan 3;10(1):40. doi: 10.3390/antibiotics10010040.
is a Gram-negative pathogen that causes plague, a devastating disease that kills millions worldwide. Although plague is efficiently treatable by recommended antibiotics, the time of antibiotic therapy initiation is critical, as high mortality rates have been observed if treatment is delayed for longer than 24 h after symptom onset. To overcome the emergence of antibiotic resistant strains, we attempted a systematic screening of Food and Drug Administration (FDA)-approved drugs to identify alternative compounds which may possess antibacterial activity against . Here, we describe a drug-repurposing approach, which led to the identification of two antibiotic-like activities of the anticancer drugs bleomycin sulfate and streptozocin that have the potential for designing novel antiplague therapy approaches. The inhibitory characteristics of these two drugs were further addressed as well as their efficiency in affecting the growth of strains resistant to doxycycline and ciprofloxacin, antibiotics recommended for plague treatment.
是一种革兰氏阴性病原体，可引发鼠疫，这是一种在全球范围内造成数百万人死亡的毁灭性疾病。尽管鼠疫可以通过推荐的抗生素有效治疗，但抗生素治疗开始的时间至关重要，因为如果在症状出现后超过24小时才开始治疗，就会观察到高死亡率。为了克服抗生素耐药菌株的出现，我们尝试对美国食品药品监督管理局（FDA）批准的药物进行系统筛选，以确定可能对具有抗菌活性的替代化合物。在此，我们描述了一种药物重新利用的方法，该方法导致鉴定出抗癌药物硫酸博来霉素和链脲佐菌素的两种类似抗生素的活性，它们有可能用于设计新型抗鼠疫治疗方法。还进一步研究了这两种药物的抑制特性以及它们对多西环素和环丙沙星耐药菌株（推荐用于鼠疫治疗的抗生素）生长的影响效率。
