Lei Chen, Kumar Suresh
Pharmacy Department, Jiangsu Vocational College of Medicine, Yancheng, China.
Doctor of Philosophy in Biomedicine, School of Graduate Studies, Management and Science University, Shah Alam, Malaysia.
Osong Public Health Res Perspect. 2022 Feb;13(1):24-36. doi: 10.24171/j.phrp.2021.0288. Epub 2022 Feb 18.
Yersinia pestis, the cause of plague and a potential biological weapon, has always been a threatening pathogen. Some strains of Y. pestis have varying degrees of antibiotic resistance. Thus, this systematic review was conducted to alert clinicians to this pathogen's potential antimicrobial resistance. A review of the literature was conducted for experimental reports and systematic reviews on the topics of plague, Y. pestis, and antibiotic resistance. From 1995 to 2021, 7 Y. pestis isolates with 4 antibiotic resistance mechanisms were reported. In Y. pestis 17/95, 16/95, and 2180H, resistance was mediated by transferable plasmids. Each plasmid contained resistance genes encoded within specific transposons. Strain 17/95 presented multiple drug resistance, since plasmid 1202 contained 10 resistance determinants. Strains 16/95 and 2180H showed single antibiotic resistance because both additional plasmids in these strains carried only 1 antimicrobial determinant. Strains 12/87, S19960127, 56/13, and 59/13 exhibited streptomycin resistance due to an rpsl gene mutation, a novel mechanism that was discovered recently. Y. pestis can acquire antibiotic resistance in nature not only via conjugative transfer of antimicrobial-resistant plasmids from other bacteria, but also by gene point mutations. Global surveillance should be strengthened to identify antibiotic-resistant Y. pestis strains by whole-genome sequencing and drug susceptibility testing.
鼠疫耶尔森菌是鼠疫的病原体，也是一种潜在的生物武器，一直是一种具有威胁性的病原体。一些鼠疫耶尔森菌菌株具有不同程度的抗生素耐药性。因此，进行了这项系统综述，以提醒临床医生注意这种病原体潜在的抗菌耐药性。针对有关鼠疫、鼠疫耶尔森菌和抗生素耐药性主题的实验报告和系统综述进行了文献检索。1995年至2021年期间，共报告了7株具有4种抗生素耐药机制的鼠疫耶尔森菌分离株。在鼠疫耶尔森菌17/95、16/95和2180H中，耐药性由可转移质粒介导。每个质粒都包含特定转座子内编码的耐药基因。菌株17/95表现出多重耐药性，因为质粒1202包含10个耐药决定簇。菌株16/95和2180H表现出单一抗生素耐药性，因为这些菌株中的另外两个质粒仅携带1个抗菌决定簇。菌株12/87、S19960127、56/13和59/13由于rpsl基因突变而表现出链霉素耐药性，这是最近发现的一种新机制。鼠疫耶尔森菌不仅可以通过从其他细菌中接合转移抗微生物耐药性质粒，还可以通过基因点突变在自然界中获得抗生素耐药性。应加强全球监测，通过全基因组测序和药敏试验来识别抗生素耐药的鼠疫耶尔森菌菌株。
