Ge Jiayan, Gu Kaiqi, Sun Kewen, Wang Xinyue, Yao Shuangquan, Mo Xiaorong, Long Shuilian, Lan Tingting, Qin Chengrong
Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, School of Light Industrial and Food Engineering, Guangxi University, Nanning 530004, China.
School of Computer and Information, Hefei University of Technology, Hefei 230009, China.
Materials (Basel). 2021 Jan 2;14(1):186. doi: 10.3390/ma14010186.
Hemicellulose-based composite hydrogels were successfully prepared by adding polydopamine (PDA) microspheres as reinforcing agents. The effects of PDA microsphere size, dosage, and nitrogen content in hydrogel on the mechanical and rheological properties was studied. The compressive strength of hydrogel was increased from 0.11 to 0.30 MPa. The storage modulus G' was increased from 7.9 to 22.0 KPa. The gaps in the hemicellulose network are filled with PDA microspheres. There is also chemical cross-linking between them. These gaps increased the density of the hydrogel network structure. It also has good water retention and pH sensitivity. The maximum cumulative release rate of methylene blue was 62.82%. The results showed that the release behavior of hydrogel was pH-responsive, which was beneficial to realizing targeted and controlling drug release.
通过添加聚多巴胺（PDA）微球作为增强剂，成功制备了基于半纤维素的复合水凝胶。研究了PDA微球尺寸、用量以及水凝胶中氮含量对力学和流变性能的影响。水凝胶的抗压强度从0.11 MPa提高到0.30 MPa。储能模量G'从7.9 KPa提高到22.0 KPa。半纤维素网络中的间隙被PDA微球填充。它们之间还存在化学交联。这些间隙增加了水凝胶网络结构的密度。它还具有良好的保水性和pH敏感性。亚甲基蓝的最大累积释放率为62.82%。结果表明，水凝胶的释放行为具有pH响应性，这有利于实现靶向控释。
