Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Curr Drug Metab. 2021;22(6):441-450. doi: 10.2174/1389200221666210105121532.
Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form, derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three-dimensional honeycombs like structure provided with two internal aqueous channels for the incorporation of many s biologically active ingredients. In contrast to liposomes, they provide a large surface area for the incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as a method of choice in the sustained release, controlled release, and targeted release dosage forms as new drug delivery system for the better release of the drugs. As a lot of advancement in the new form of dosage form brought the novel avenues in drug delivery mechanisms, so it was a matter of worth to compile the latest updates on the various aspects of the mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health-related benefits.
立方脂质体是一种高度稳定的纳米结构液晶给药形式，由两亲性脂质和基于聚合物的稳定剂衍生而来，将其转化为药物传递的有效生物相容性载体。该给药形式由双连续脂质双层组成，呈三维蜂窝状结构，具有两个内部水通道，可容纳多种生物活性成分。与脂质体相比，它们为不同类型成分的掺入提供了更大的表面积。由于生物相容性和热力学稳定性的明显优势，立方脂质体仍然是作为持续释放、控制释放和靶向释放剂型的首选方法，作为新的药物传递系统，以更好地释放药物。由于新剂型的许多进展为药物传递机制带来了新的途径，因此编译有关所述治疗性递药系统各个方面的最新更新内容是值得的，包括其结构、应用途径以及封装各种药物以提供与健康相关益处的潜在应用。
