Duttagupta Aindrilla S, Chaudhary Harsiddhi M, Jadhav Kisan R, Kadam Vilasrao J
University of Mumbai, Bharati Vidyapeeth's College of Pharmacy, Department of Pharmaceutics, CBD Belapur, Sector-8, Navi-Mumbai-400614, India.
Curr Drug Deliv. 2016;13(4):482-93. doi: 10.2174/1567201812666150224114751.
Some amphiphilic lipids can self-assemble to form bicontinuous cubic liquid crystalline materials in aqueous media. These cubic structures have gained considerable attention since they impart unique properties of practical interest. Cubosomes, being dispersions of an inverted type bicontinuous cubic phase, separate two continuous aqueous regions with a lipid bilayer having the propensity to incorporate drugs of varying polar characteristics. These novel versatile materials possess the properties to form a section of the next generation of advanced biocompatible nanoparticles.
This review chiefly considers the scope and importance of cubosomes as a proficient drug delivery vehicle. In addition, it also takes into account the various methods of preparation, the drug loading and release behavior as well as different methods of characterization. Their current advances in various arenas ranging from sustained drug release, burn management, melanoma therapy, vaccine delivery, protein delivery, cosmeceutical and theranostic applications are briefly summarized in this overview.
The drug release from cubosomal dispersions have shown enhancement in bioavailability by solubilisation of poorly water soluble drugs, decrease in adverse effects, enhancement of intracellular penetration, protection against degradation, possibility of sustained drug release and the biodegradable nature of lipids is an added advantage.
Recognizing the desirable properties of cubosomes, it has been proposed as a novel carrier for drug delivery systems. Their unique solubilizing, encapsulating, transporting and protecting capabilities make them an attractive vehicle for numerous in vivo drug delivery routes.
一些两亲性脂质在水性介质中可自组装形成双连续立方液晶材料。这些立方结构因其具有实际应用中独特的性质而备受关注。立方液晶纳米粒作为反相双连续立方相的分散体，通过具有容纳不同极性特征药物倾向的脂质双层分隔两个连续的水相区域。这些新型多功能材料具有形成下一代先进生物相容性纳米颗粒的特性。
本综述主要探讨立方液晶纳米粒作为一种高效药物递送载体的范围和重要性。此外，还考虑了其各种制备方法、载药和释药行为以及不同的表征方法。本文概述简要总结了它们在从缓释药物、烧伤处理、黑色素瘤治疗、疫苗递送、蛋白质递送、药妆和诊疗应用等各个领域的当前进展。
立方液晶纳米粒分散体的药物释放显示出通过增溶难溶性药物提高了生物利用度、减少了不良反应、增强了细胞内渗透、防止降解、实现了药物缓释的可能性，并且脂质的生物可降解性是一个额外的优势。
鉴于立方液晶纳米粒的理想特性，已提出将其作为药物递送系统的新型载体。它们独特的增溶、包封、运输和保护能力使其成为众多体内药物递送途径的有吸引力的载体。
