Burnet Institute, Melbourne, Australia; Department of Immunology and Pathology, Monash University, Melbourne, Australia.
Burnet Institute, Melbourne, Australia; Department of Immunology and Pathology, Monash University, Melbourne, Australia; Central Clinical School and Department of Microbiology, Monash University, Melbourne, Australia; Department of Medicine, The University of Melbourne, Parkville, Australia.
Trends Immunol. 2021 Feb;42(2):94-103. doi: 10.1016/j.it.2020.12.002. Epub 2020 Dec 13.
Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been overshadowed by reports of extensive complement activation in severe coronavirus disease 2019 (COVID-19) patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics and vaccines against SARS-CoV-2.
补体是健康的免疫系统的重要组成部分，它可以协调针对病毒和其他病原体的各种先天和适应性反应。尽管补体非常重要，但是在严重的 2019 年冠状病毒病（COVID-19）患者中广泛报道补体激活的情况下，补体在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）免疫中的潜在有益作用已被掩盖。在这里，我们假设补体也可能具有保护作用，并可以通过抗体增强病毒中和作用、促进免疫细胞吞噬病毒以及病毒溶解等功能。这些功能可能会被利用于开发针对 SARS-CoV-2 的有效治疗方法和疫苗。
