Harvard Medical School, Boston, Massachusetts.
Department of Pediatric Allergy and Immunology, Stanford University, Stanford, California.
Pediatr Pulmonol. 2020 Oct;55(10):2556-2564. doi: 10.1002/ppul.24981. Epub 2020 Aug 4.
The difference in morbidity and mortality between adult and pediatric coronavirus disease 2019 infections is dramatic. Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. The goal of this review is to highlight research developments in the understanding of the immune responses to SARS-CoV-2 infections, with a specific focus on age-related immune responses.
成人和儿童 2019 年冠状病毒病感染的发病率和死亡率差异巨大。了解严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）对儿童的急性和延迟性特异性免疫反应对于疫苗接种策略、免疫靶向治疗以及儿童多系统炎症综合征的治疗和预防至关重要。本综述的目的是强调对 SARS-CoV-2 感染免疫反应的研究进展，特别关注与年龄相关的免疫反应。
