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Serotonin is elevated in COVID-19-associated diarrhoea.血清素在新冠病毒相关腹泻中升高。
Gut. 2021 Oct;70(10):2015-2017. doi: 10.1136/gutjnl-2020-323542. Epub 2021 Jan 5.
2
Single-cell gene expression links SARS-CoV-2 infection and gut serotonin.单细胞基因表达揭示了新冠病毒感染与肠道血清素之间的联系。
Gut. 2023 Jul;72(7):1430-1431. doi: 10.1136/gutjnl-2022-328262. Epub 2022 Aug 23.
3
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.严重的 COVID-19 以羧肽酶 A3 和血清素的失调血清水平为特征。
J Leukoc Biol. 2021 Sep;110(3):425-431. doi: 10.1002/JLB.4HI0221-087R. Epub 2021 May 31.
4
SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染导致新型冠状病毒肺炎（COVID-19）患者出现腹泻作为首发症状。
Gut. 2020 Jun;69(6):1143-1144. doi: 10.1136/gutjnl-2020-320891. Epub 2020 Mar 5.
5
Low incidence rate of diarrhoea in COVID-19 patients is due to integrin.新冠病毒肺炎患者腹泻发生率低是由于整合素。
J Infect. 2021 Oct;83(4):496-522. doi: 10.1016/j.jinf.2021.07.007. Epub 2021 Jul 15.
6
COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota.新型冠状病毒肺炎：血小板、线粒体、维生素 D、血清素和肠道微生物群的意义。
Curr Med Chem. 2021;28(37):7634-7657. doi: 10.2174/0929867328666210526100147.
7
Diarrhoea: An Atypical Presentation of COVID-19.腹泻：新型冠状病毒肺炎的一种非典型表现
J Coll Physicians Surg Pak. 2020 Jun;30(6):40-42. doi: 10.29271/jcpsp.2020.Supp1.S40.
8
The digestive system and the COVID-19.消化系统与新型冠状病毒肺炎
J Pak Med Assoc. 2020 May;70(Suppl 3)(5):S98-S100. doi: 10.5455/JPMA.19.
9
Rare presentation of multisystem inflammatory syndrome in an adult associated with SARS-CoV-2 infection: unilateral neck swelling.成人中与SARS-CoV-2感染相关的多系统炎症综合征的罕见表现：单侧颈部肿胀。
BMJ Case Rep. 2021 May 12;14(5):e242392. doi: 10.1136/bcr-2021-242392.
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Metabolic rewiring and serotonin depletion in patients with postacute sequelae of COVID-19.新冠后急性后遗症患者的代谢重编程与血清素耗竭
Allergy. 2022 May;77(5):1623-1625. doi: 10.1111/all.15253. Epub 2022 Feb 17.

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Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome.长新冠慢性疲劳综合征患者的代谢组学和免疫改变。
Front Immunol. 2024 Jan 18;15:1341843. doi: 10.3389/fimmu.2024.1341843. eCollection 2024.
2
COVID-19 and Gastrointestinal Tract: From Pathophysiology to Clinical Manifestations.新型冠状病毒肺炎与消化道：从病理生理学到临床表现。
Medicina (Kaunas). 2023 Sep 24;59(10):1709. doi: 10.3390/medicina59101709.
3
Synergistic Interaction of 5-HT and 5-HT Receptors in Cytoplasmic Ca Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.5-HT 和 5-HT 受体在人脐静脉内皮细胞细胞质 Ca 调节中的协同作用：可能涉及病理学。
Int J Mol Sci. 2023 Sep 8;24(18):13833. doi: 10.3390/ijms241813833.
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Epidemiological features and consequences of COVID-19 in patients with and without gastrointestinal symptoms in southwestern Iran. A retrospective observational study.伊朗西南部有和没有胃肠道症状的COVID-19患者的流行病学特征及后果。一项回顾性观察研究。
Health Sci Rep. 2023 Sep 18;6(9):e1499. doi: 10.1002/hsr2.1499. eCollection 2023 Sep.
5
Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections.肠神经系统作为 SARS-CoV-2 及其他病毒感染的靶标和来源。
Am J Physiol Gastrointest Liver Physiol. 2023 Aug 1;325(2):G93-G108. doi: 10.1152/ajpgi.00229.2022. Epub 2023 May 30.
6
COVID-19 and diarrhea: putative mechanisms and management.新型冠状病毒肺炎与腹泻：可能的发病机制与治疗管理。
Int J Infect Dis. 2023 Jan;126:125-131. doi: 10.1016/j.ijid.2022.11.018. Epub 2022 Nov 17.
7
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysis.使用 LC/MS 分析鉴定血清素作为 COVID-19 严重程度和预后的候选生物标志物。
J Pharmacol Sci. 2022 Oct;150(2):49-55. doi: 10.1016/j.jphs.2022.06.005. Epub 2022 Jul 31.
8
Single-cell gene expression links SARS-CoV-2 infection and gut serotonin.单细胞基因表达揭示了新冠病毒感染与肠道血清素之间的联系。
Gut. 2023 Jul;72(7):1430-1431. doi: 10.1136/gutjnl-2022-328262. Epub 2022 Aug 23.
9
Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality.基于假设无关网络的真实世界数据分析表明，昂丹司琼与降低新冠病毒感染所致任何原因死亡率相关。
Drugs Real World Outcomes. 2022 Sep;9(3):359-375. doi: 10.1007/s40801-022-00303-9. Epub 2022 Jul 9.
10
The relationship between the serotonergic system and COVID-19 disease: A review.血清素能系统与新型冠状病毒肺炎的关系：综述
Heliyon. 2022 May;8(5):e09544. doi: 10.1016/j.heliyon.2022.e09544. Epub 2022 May 26.

本文引用的文献

1
COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract.COVID-19 大流行：胃肠道的病理生理学和表现。
World J Gastroenterol. 2020 Aug 21;26(31):4579-4588. doi: 10.3748/wjg.v26.i31.4579.
2
An inflammatory cytokine signature predicts COVID-19 severity and survival.炎症细胞因子特征可预测 COVID-19 严重程度和存活情况。
Nat Med. 2020 Oct;26(10):1636-1643. doi: 10.1038/s41591-020-1051-9. Epub 2020 Aug 24.
3
GI symptoms as early signs of COVID-19 in hospitalised Italian patients.意大利住院患者中胃肠道症状作为新冠病毒疾病的早期迹象
Gut. 2020 Aug;69(8):1547-1548. doi: 10.1136/gutjnl-2020-321434. Epub 2020 May 14.
4
Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection.95 例 SARS-CoV-2 感染患者的胃肠道症状。
Gut. 2020 Jun;69(6):997-1001. doi: 10.1136/gutjnl-2020-321013. Epub 2020 Apr 2.
5
Serotonin: A Potent Immune Cell Modulator in Autoimmune Diseases.血清素：自身免疫性疾病中的一种强效免疫细胞调节剂。
Front Immunol. 2020 Feb 11;11:186. doi: 10.3389/fimmu.2020.00186. eCollection 2020.
6
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.
7
Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.药物治疗对腹泻型肠易激综合征或混合型肠易激综合征患者的疗效：系统评价和网络荟萃分析。
Gut. 2020 Jan;69(1):74-82. doi: 10.1136/gutjnl-2018-318160. Epub 2019 Apr 17.
8
The Intestinal Microenvironment and Functional Gastrointestinal Disorders.肠道微环境与功能性胃肠疾病
Gastroenterology. 2016 Feb 18. doi: 10.1053/j.gastro.2016.02.028.
9
The serotonin signaling system: from basic understanding to drug development for functional GI disorders.5-羟色胺信号系统：从基础认识到功能性胃肠疾病的药物研发
Gastroenterology. 2007 Jan;132(1):397-414. doi: 10.1053/j.gastro.2006.11.002.
10
Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.便秘型和腹泻型肠易激综合征患者5-羟色胺信号改变
Gastroenterology. 2006 Jan;130(1):34-43. doi: 10.1053/j.gastro.2005.09.031.

Serotonin is elevated in COVID-19-associated diarrhoea.

作者信息

Ha Seeun, Jin Byungchang, Clemmensen Brooke, Park Paul, Mahboob Sumaiya, Gladwill Vadim, Lovely Farah Madhani, Gottfried-Blackmore Andres, Habtezion Aida, Verma Subhash, Ro Seungil

机构信息

Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada, USA.

Internal Medicine, University of Nevada School of Medicine, Reno, Nevada, USA.

出版信息

Gut. 2021 Oct;70(10):2015-2017. doi: 10.1136/gutjnl-2020-323542. Epub 2021 Jan 5.

DOI:10.1136/gutjnl-2020-323542
PMID:33402416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9208360/
Abstract
摘要