Department of Pathology, Seoul Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
Department of Surgery, Seoul Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.
In Vivo. 2021 Jan-Feb;35(1):131-140. doi: 10.21873/invivo.12240.
BACKGROUND/AIM: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples.
DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival.
Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis.
Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis.
背景/目的：双特异性蛋白磷酸酶 4（DUSP4）负调控 MAPK 信号转导，并参与多种细胞过程。本研究旨在评估 DUSP4 表达与大型胃癌样本临床病理特征之间的关系。
采用免疫组织化学法检测 508 例胃癌组织中 DUSP4 的表达。根据 TCGA 分子分类和 HER2 扩增情况对病例进行分类。Kaplan-Meier 图用于预测 DUSP4 mRNA 表达与生存之间的关系。
DUSP4 低表达与肿瘤体积较大、pT 分期较高、淋巴结阳性、分期较高、淋巴管浸润、神经周围浸润、总生存期较差和无复发生存期较差显著相关。DUSP4 表达与分子特征之间无相关性。生物信息学分析显示，低 mRNA 表达与胃癌不良预后相关。
DUSP4 低表达与胃癌侵袭性表型和不良预后相关。
