亚硫酸盐氧化酶是晚期胃癌的一种新型预后生物标志物。
Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer.
机构信息
Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan;
出版信息
In Vivo. 2021 Jan-Feb;35(1):229-237. doi: 10.21873/invivo.12251.
BACKGROUND/AIM: Sulfite oxidase (SUOX) is an enzyme present in the mitochondria, which has been demonstrated to be correlated with various malignant tumours.
MATERIALS AND METHODS
We evaluated SUOX expression in tissues of 98 cases of advanced gastric cancer and performed a clinicopathological assessment for metrics.
RESULTS
Among 98 cases, 55 cases were classified into the SUOX low expression group, and 43 cases into the SUOX high expression group. There were more pStage IV cases in the low expression group. The median overall survival of the low expression group was shorter than that of the high expression group (p=0.020). In univariate and multivariate analysis, SUOX low expression level (p=0.039) and pStage (p<0.001) were independent prognostic factors.
CONCLUSION
SUOX is an independent prognostic factor. Therefore, SUOX expression could also serve as a useful marker for elucidating the mechanism of gastric cancer proliferation and progression.
背景/目的：亚硫酸氧化酶（SUOX）是一种存在于线粒体中的酶，已被证明与各种恶性肿瘤相关。
材料与方法
我们评估了 98 例晚期胃癌组织中的 SUOX 表达，并进行了临床病理评估。
结果
在 98 例中，55 例被归类为 SUOX 低表达组，43 例为 SUOX 高表达组。低表达组中 pStage IV 病例较多。低表达组的中位总生存期短于高表达组（p=0.020）。单因素和多因素分析表明，SUOX 低表达水平（p=0.039）和 pStage（p<0.001）是独立的预后因素。
结论
SUOX 是一个独立的预后因素。因此，SUOX 表达也可以作为阐明胃癌增殖和进展机制的有用标志物。
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