Kurose Hirofumi, Naito Yoshiki, Akiba Jun, Kondo Reiichiro, Ogasawara Sachiko, Kusano Hironori, Sanada Sakiko, Abe Hideyuki, Kakuma Tatsuyuki, Ueda Kosuke, Igawa Tsukasa, Yano Hirohisa
Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Department of Urology, Kurume University School of Medicine, Kurume, Japan.
Med Mol Morphol. 2019 Sep;52(3):164-172. doi: 10.1007/s00795-018-00214-1. Epub 2019 Jan 10.
Sulfite oxidase (SUOX) is a metalloenzyme that plays a role in ATP synthesis via oxidative phosphorylation in mitochondria and has been reported to also be involved in the invasion and differentiation capacities of tumor cells. Here, we performed a clinicopathological investigation of SUOX expression in prostate cancer and discussed the usefulness of SUOX expression as a predictor of biochemical recurrence following surgical treatment in prostate cancer. This study was conducted using Tissue Micro Array specimens obtained from 97 patients who underwent radical prostatectomy at our hospital between 2007 and 2011. SUOX staining was used to evaluate cytoplasmic SUOX expression. In the high-expression group, the early biochemical recurrence was significantly more frequent than in the low-expression group (p = 0.0008). In multivariate analysis, high SUOX expression was found to serve as an independent prognostic factor of biochemical recurrence (hazard ratio = 2.33, 95% confidence interval = 1.32-4.15, p = 0.0037). In addition, Ki-67-labeling indices were significantly higher in the high-expression group than in the low-expression group (p = 0.0058). Therefore, SUOX expression may be a powerful prognostic biomarker for decision-making in postoperative follow-up after total prostatectomy and with regard to the need for relief treatment.
亚硫酸盐氧化酶（SUOX）是一种金属酶，通过线粒体中的氧化磷酸化作用参与三磷酸腺苷（ATP）的合成，据报道它还与肿瘤细胞的侵袭和分化能力有关。在此，我们对前列腺癌中SUOX的表达进行了临床病理研究，并探讨了SUOX表达作为前列腺癌手术治疗后生化复发预测指标的实用性。本研究使用了从2007年至2011年在我院接受根治性前列腺切除术的97例患者中获取的组织微阵列标本。采用SUOX染色评估细胞质中SUOX的表达。在高表达组中，早期生化复发的发生率明显高于低表达组（p = 0.0008）。多因素分析显示，SUOX高表达是生化复发的独立预后因素（风险比 = 2.33，95%置信区间 = 1.32 - 4.15，p = 0.0037）。此外，高表达组的Ki-67标记指数显著高于低表达组（p = 0.0058）。因此，SUOX表达可能是前列腺全切术后随访决策以及确定是否需要缓解治疗的一个有力预后生物标志物。
