钠离子（Na）磁共振成像在阿尔茨海默病患者神经退行性改变中的生物标志物和预测评估。
Evaluation of Sodium (Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer's Disease.
机构信息
Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;
Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
出版信息
In Vivo. 2021 Jan-Feb;35(1):429-435. doi: 10.21873/invivo.12275.
BACKGROUND/AIM: Sodium (Na) MR imaging is a noninvasive MRI technique that has been shown to be sensitive to visualize biochemical information about tissue viability, their cell integrity, and cell function in various studies. The aim of this study was to evaluate differences in regional brain Na signal intensity between Alzheimer's disease (AD) and healthy controls to preliminarily evaluate the capability of Na imaging as a biomarker for AD.
PATIENTS AND METHODS
A total of 14 patients diagnosed with AD were included: 12 in the state of dementia and 2 with mild cognitive impairment (MCI), and 12 healthy controls (HC); they were all scanned on a 3T clinical scanner with a double tuned H/Na birdcage head coil. After normalizing the signal intensity with that of the vitreous humor, relative tissue sodium concentration (rTSC) was measured after automated segmentation in the hippocampus, amygdala, basal ganglia, white matter (WM) and grey matter (GM) in both cerebral hemispheres.
RESULTS
Patients with AD showed a significant increase in rTSC in comparison to healthy controls in the following brain regions: WM 13.6%; p=0.007, hippocampus 12.9%; p=0.003, amygdala 18.9%; p=0.0007.
CONCLUSION
Na-MRI has the potential to be developed as a useful biomarker for the diagnosis of AD.
背景/目的：钠（Na）磁共振成像是一种非侵入性 MRI 技术，已被证明在各种研究中对组织活力、细胞完整性和细胞功能的生化信息具有敏感性。本研究的目的是评估阿尔茨海默病（AD）和健康对照者之间大脑区域 Na 信号强度的差异，初步评估 Na 成像作为 AD 生物标志物的能力。
患者与方法
共纳入 14 例 AD 患者：12 例痴呆状态和 2 例轻度认知障碍（MCI），12 例健康对照者（HC）；所有患者均在 3T 临床扫描仪上用双调谐 H/Na 鸟笼头线圈进行扫描。在将信号强度与玻璃体液的信号强度归一化后，在自动分割双侧大脑的海马体、杏仁核、基底节、白质（WM）和灰质（GM）后，测量相对组织钠浓度（rTSC）。
结果
与健康对照组相比，AD 患者的 rTSC 在以下脑区显著增加：WM 为 13.6%；p=0.007，海马体为 12.9%；p=0.003，杏仁核为 18.9%；p=0.0007。
结论
Na-MRI 有可能发展成为 AD 诊断的有用生物标志物。
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