Wawrzyniak Pawel, Hebda Anna, Awramienko-Włoczek Aleksandra, Mazgaj Patrycja, Heinze Sylwia, Bobek-Billewicz Barbara
Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.
Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Cracow Branch, Poland.
Pol J Radiol. 2023 Jul 28;88:e343-e348. doi: 10.5114/pjr.2023.130252. eCollection 2023.
The purpose of this work was to establish a database of tissue sodium concentration (TSC) in the normal brain of healthy volunteers. Tissue sodium concentration can be used as a sensitive marker of tissue viability in stroke or radiation therapy monitoring.
Thirty-seven volunteers were scanned with a Na protocol in the span of one year; within this group, 29 studies were of acceptable quality. The study was approved by the Local Bioethics Committee. Data were acquired during a single magnetic resonance (MR) scanner session. The single scanner session consisted of Na 3D radial gradient echo (GRE) acquisition, MPRage, SPACE-FLAIR, and Resolve-DTI. MPRage images were segmented to obtain masks of the grey matter (GM), white matter (WM), and cerebrospinal fluid (CSF), which were registered to the sodium image space for image analysis. Images were transformed into TSC maps - a signal calibration curve obtained from the reference phantom of known sodium concentration and known relaxation time.
The collected data were analysed in 2 different ways: volunteers were divided by sex and by age. No significant differences in TSC were found between sexes. In all comparisons there was a significant difference in TSC between younger and older volunteers. In healthy volunteers mean TSC were as follows: GM 33.21 ± 4.76 mmol/l, WM 28.41 ± 4.03 mmol/l and for CSF 41.3 ± 6.69 mmol/l.
This preliminary work is a base for further work with sodium imaging in brain lesions. The entirety of the col-lected data will be useful in the future as a baseline brain TSC for comparison to values obtained from pathologies.
本研究旨在建立健康志愿者正常脑内组织钠浓度（TSC）数据库。组织钠浓度可作为中风或放射治疗监测中组织活力的敏感标志物。
37名志愿者在1年内采用钠成像方案进行扫描；该组中，29项研究质量合格。本研究经当地生物伦理委员会批准。数据在单次磁共振（MR）扫描过程中采集。单次扫描包括钠三维径向梯度回波（GRE）采集、MPRage、SPACE-FLAIR和Resolve-DTI。对MPRage图像进行分割，以获得灰质（GM）、白质（WM）和脑脊液（CSF）的掩膜，并将其配准到钠图像空间进行图像分析。图像被转换为TSC图——从已知钠浓度和已知弛豫时间的参考体模获得的信号校准曲线。
收集的数据采用两种不同方式进行分析：按性别和年龄对志愿者进行分组。未发现不同性别之间TSC存在显著差异。在所有比较中，年轻和年长志愿者之间的TSC存在显著差异。健康志愿者的平均TSC如下：GM为33.21±4.76 mmol/l，WM为28.41±4.03 mmol/l，CSF为41.3±6.69 mmol/l。
这项初步工作是进一步开展脑病变钠成像研究的基础。收集的所有数据将来可作为脑TSC基线，用于与病理状态下获得的值进行比较。
