Gaziosmanpaşa University Faculty of Medicine, Department of Internal Medicine.
Department of Biochemistry.
Afr Health Sci. 2020 Mar;20(1):277-286. doi: 10.4314/ahs.v20i1.33.
Insulin resistance (IR) is one of the most important etiological risk factors in the development of diabetes. However, there is no clear data regarding the prevalence of IR in the country.
This study evaluates the prevalence of IR and identifies the optimal threshold values for the HOMA indexes in Turkey.
This cross-sectional, population-based survey includes 2013 participants aged 20-84 years. The values of the anthropometric measurements and laboratory analysis were recorded. The 90 percentile in the non-obese and non-diabetic population was accepted as cut-off values for IR.
The optimal threshold values for IR were 2.46 in HOMA1-IR and 1.40 in HOMA2-IR. Using the HOMA2-IR method, the overall prevalence of IR was 33.2%. The IR prevalence was higher in women (35.6%) compared to men (30.1%) [p=0.008]. There was a higher IR prevalence in men living in urban areas (p=0.001), not in women. The multivariate logistic regression analysis showed that gender, serum glucose level, serum levels of triglycerides and high-density lipoprotein cholesterol, bodymass index and income status were associated with insulin resistance.
The cut-off values of HOMA1-IR and HOMA2-IR were determined in this study and we believe that these findings will be helpful to clinicians in the fight against health problems such as diabetes.
胰岛素抵抗（IR）是糖尿病发展最重要的病因学危险因素之一。然而，关于该国 IR 的患病率尚没有明确的数据。
本研究评估了土耳其的 IR 患病率，并确定了 HOMA 指数的最佳阈值。
这是一项横断面、基于人群的调查，共纳入 2013 名年龄在 20-84 岁的参与者。记录了人体测量和实验室分析的值。将非肥胖和非糖尿病人群中的第 90 百分位数作为 IR 的截断值。
IR 的最佳 HOMA1-IR 和 HOMA2-IR 截断值分别为 2.46 和 1.40。使用 HOMA2-IR 方法，IR 的总患病率为 33.2%。女性（35.6%）的 IR 患病率高于男性（30.1%）（p=0.008）。居住在城市地区的男性（p=0.001）IR 患病率较高，但女性则不然。多变量逻辑回归分析显示，性别、血清葡萄糖水平、血清甘油三酯和高密度脂蛋白胆固醇水平、体重指数和收入状况与胰岛素抵抗有关。
本研究确定了 HOMA1-IR 和 HOMA2-IR 的截断值，我们相信这些发现将有助于临床医生对抗糖尿病等健康问题。
