稳态模型评估与甘油三酯葡萄糖指数在评估HIV感染患者胰岛素抵抗中的一致性
Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients.
作者信息
Budak Gokcen Gurkok, Vatan Aslı, Güçlü Ertuğrul, Karabay Oğuz
机构信息
From the Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
出版信息
Saudi Med J. 2025 Feb;46(2):157-162. doi: 10.15537/smj.2025.46.2.20240769.
OBJECTIVES
To evaluate the concordance between the triglyceride glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) in assessing insulin resistance (IR) in people living with HIV (PLWH). Additionally, we aimed to estimate a cut-off value for the TyG index in PLWH.
METHODS
This retrospective, observational study included medical records of patients diagnosed with HIV at Sakarya Training and Research Hospital from January 2019 to January 2024. Based on their HOMA-IR levels, PLWH patients were divided into 2 groups: Group A (patients without IR) and Group B (patients with IR).
RESULTS
In this study, insulin resistance was investigated in 147 people living with HIV (PLWH) between the ages of 18-68. Our results showed a significant positive linear relationship between HOMA-IR and the TyG index (r=0.628, <0.001). We found the TyG Index cut-off value to predict IR in people living with HIV (PLWH) to be 8.25.
CONCLUSION
Our study identified correlation between the TyG index and HOMA IR index in PLWH. The TyG index may serve as an effective alternative to HOMA-IR for evaluating insulin resistance in PLWH.".
目的
评估甘油三酯葡萄糖（TyG）指数与胰岛素抵抗稳态模型评估（HOMA-IR）在评估HIV感染者（PLWH）胰岛素抵抗（IR）方面的一致性。此外，我们旨在估计PLWH中TyG指数的临界值。
方法
这项回顾性观察性研究纳入了2019年1月至2024年1月在萨卡里亚培训和研究医院被诊断为HIV的患者的病历。根据HOMA-IR水平，PLWH患者被分为两组：A组（无IR的患者）和B组（有IR的患者）。
结果
在本研究中，对147名年龄在18-68岁之间的HIV感染者（PLWH）进行了胰岛素抵抗调查。我们的结果显示HOMA-IR与TyG指数之间存在显著的正线性关系（r=0.628，<0.001）。我们发现预测HIV感染者（PLWH）IR的TyG指数临界值为8.25。
结论
我们的研究确定了PLWH中TyG指数与HOMA IR指数之间的相关性。TyG指数可作为评估PLWH胰岛素抵抗的一种有效的替代HOMA-IR的方法。
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