Celık Zehra Margot, Sargin Mehmet, Tamer Havva Gonca, Gunes Fatma Esra
Department of Nutrition and Dietetics Marmara University Faculty of Health Sciences Istanbul Turkey.
Faculty of Medicine, Family Medicine Istanbul Medeniyet University Istanbul Turkey.
Food Sci Nutr. 2023 Oct 8;11(12):8060-8071. doi: 10.1002/fsn3.3725. eCollection 2023 Dec.
The aim of this study was to determine the effect on the anthropometric and biochemical parameters for women with insulin resistance when lyophilized dried cornelian cherry ( L., CM) was added to medical nutrition therapy (MNT). The study was conducted with 84 women aged 18-45, who had been diagnosed with insulin resistance. Participants were randomized into four groups: MNT + 20 g lyophilized dried CM group (DCm, = 22), MNT group (D, = 21), only 20 g lyophilized dried CM group (Cm, = 21), and the control group (C, = 20). All participants were followed for 12 weeks. While pre- and post-intervention biochemical parameters were recorded from patient files, anthropometric measurements and food consumption records were taken every 15 days. Pre-intervention groups were homogeneously distributed. Post-intervention, among the groups, all anthropometric measurements were similar between the DCm and D, while the percentage of decrease in insulin resistance-related parameters was approximately two times greater in DCm than in D ( < .05). When the Cm and C were compared, it was found that all post-intervention anthropometric measurements were similar, but the percentage of decrease in fasting blood glucose, fasting insulin, and HOMA-IR (Homeostasis Model Assessment-Insulin Resistance) values were greater in C ( < .05). In this study, it was concluded that CM consumption resulted with a decrease in insulin resistance-related biochemical parameters independent of body weight change. Nevertheless, MNT has positive effects on women with insulin resistance, and adding lyophilized dried CM to MNT improves insulin resistance-related parameters and may be beneficial for preventing the development of diabetes.
本研究的目的是确定在医学营养疗法（MNT）中添加冻干山茱萸（L.，CM）对胰岛素抵抗女性的人体测量和生化参数的影响。该研究对84名年龄在18 - 45岁、被诊断为胰岛素抵抗的女性进行。参与者被随机分为四组：MNT + 20克冻干山茱萸组（DCm，n = 22）、MNT组（D，n = 21）、仅20克冻干山茱萸组（Cm，n = 21）和对照组（C，n = 20）。所有参与者均随访12周。从患者病历中记录干预前后的生化参数，每15天进行一次人体测量和食物消费记录。干预前各组分布均匀。干预后，在各组中，DCm组和D组之间的所有人体测量值相似，而DCm组中胰岛素抵抗相关参数的下降百分比约为D组的两倍（P < 0.05）。比较Cm组和C组时发现，干预后所有人体测量值相似，但C组空腹血糖、空腹胰岛素和HOMA-IR（稳态模型评估-胰岛素抵抗）值的下降百分比更大（P < 0.05）。在本研究中，得出的结论是，食用山茱萸可导致与胰岛素抵抗相关的生化参数下降，且与体重变化无关。然而，MNT对胰岛素抵抗女性有积极作用，在MNT中添加冻干山茱萸可改善与胰岛素抵抗相关的参数，可能有助于预防糖尿病的发展。
