在尼日利亚西南部，与 HIV 共感染的女性中单纯疱疹病毒 2 型和另外两种致癌病毒的共存与宫颈病变有关。
Co-existence of Herpes simplex virus type 2 and two other oncoviruses is associated with cervical lesions in women living with HIV in South-Western Nigeria.
机构信息
Nnamdi Azikiwe University, Medical Laboratory Science; Babcock University, Medical Laboratory Science.
Nnamdi Azikiwe University, Medical Laboratory Science.
出版信息
Afr Health Sci. 2020 Sep;20(3):1015-1023. doi: 10.4314/ahs.v20i3.4.
BACKGROUND
The prevalence of Herpes simplex virus type 2 (HSV-2) in cervical lesions is under-reported, especially in Human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) and Human Papillomavirus (HPV) infected persons.
OBJECTIVES
This study determined the prevalence of viral mono-infections, co-infections and squamous cell intraepithelial lesions (SIL) in HIV seropositive (HIV+) and HIV seronegative (HIV-) women.
METHODS
This study included HIV+ and HIV- women (105 each). Cervical smears and viral antibodies were evaluated by Papanicolaou's technique and ELISA method, respectively.
RESULTS
The prevalence of HSV-2, HPV and EBV infections, and SIL were higher in HIV+ women (75.2, 41.9, 41 and 32.4%) than in HIV- women (45.7, 26.7, 26.7 and 13.3%) at p< 0.0001, p= 0.029, 0.041 and 0.002, respectively. Higher prevalence of viral mono-infection and tri-infection was observed in HIV+ women (43.8 and 24.8%) than in HIV- women (27.6 and 8.6%) at p= 0.021, and 0.003, respectively. The prevalence of SIL was also higher in HIV+ women with viral mono-infection, bi-infection and tri-infection (15.2, 42.9, and 53.8%) than in HIV- women (6.9, 12.5, and 44.4%) at p= 0.468, 0.041, and 0.711, respectively.
CONCLUSION
This study suggests that the high prevalence of SIL in HIV+ women could be associated with viral co-infections.
背景
单纯疱疹病毒 2 型（HSV-2）在宫颈病变中的流行率被低估，尤其是在人类免疫缺陷病毒（HIV）、爱泼斯坦-巴尔病毒（EBV）和人乳头瘤病毒（HPV）感染者中。
目的
本研究旨在确定 HIV 阳性（HIV+）和 HIV 阴性（HIV-）妇女中病毒单纯感染、合并感染和鳞状上皮内病变（SIL）的流行率。
方法
本研究纳入了 105 例 HIV+和 105 例 HIV-妇女。采用巴氏涂片技术和 ELISA 法分别评估宫颈涂片和病毒抗体。
结果
HIV+妇女中 HSV-2、HPV 和 EBV 感染以及 SIL 的流行率高于 HIV-妇女（75.2%、41.9%、41%和 32.4%比 45.7%、26.7%、26.7%和 13.3%，p<0.0001）。HIV+妇女中病毒单纯感染和三重感染的流行率更高（43.8%和 24.8%比 27.6%和 8.6%，p=0.021 和 0.003）。HIV+妇女中病毒单纯感染、双重感染和三重感染的 SIL 流行率也更高（15.2%、42.9%和 53.8%比 6.9%、12.5%和 44.4%，p=0.468、0.041 和 0.711）。
结论
本研究表明，HIV+妇女中 SIL 的高流行率可能与病毒合并感染有关。
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