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一名合并 COVID-19 感染的结核病患者因轴索性神经病导致双侧足下垂:病例报告

Bilateral Foot-Drop Secondary to Axonal Neuropathy in a Tuberculosis Patient With Co-Infection of COVID-19: A Case Report.

作者信息

AlKhateeb Mohammad H, Aziz Afia, Eltahir Mugahid, Elzouki Abdulnasser

机构信息

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

出版信息

Cureus. 2020 Nov 28;12(11):e11734. doi: 10.7759/cureus.11734.

DOI:10.7759/cureus.11734
PMID:33403166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7773300/
Abstract

Tuberculosis (TB) is a global pandemic and is one of the top 10 causes of death worldwide as well as the leading cause of death from a single infectious agent.It can cause a wide array of complications including peripheral neuropathy. In addition to TB pandemic the recent pandemic of coronavirus disease 2019 (COVID-19) has led to an increased interest in the co-infection of TB patients and COVID-19 and whether TB increases risk for COVID-19 and its role in causing severity of disease and vice-versa.This case report discusses about a young cachectic man who was found to have bilateral foot-drop under the setting of TB with co-infection of COVID-19 later confirmed to be axonal neuropathy on nerve conduction study. The report highlights the importance of differential diagnosis of TB in COVID-19 patients as well as the consideration of TB in a patient with peripheral neuropathy after nutritional causes have been ruled out.

摘要

结核病(TB)是一种全球大流行病,是全球十大死因之一,也是单一传染源导致死亡的主要原因。它可引发多种并发症,包括周围神经病变。除了结核病大流行外,近期的2019冠状病毒病(COVID-19)大流行引发了人们对结核病患者与COVID-19合并感染的更多关注,以及结核病是否会增加感染COVID-19的风险及其在导致疾病严重程度方面的作用,反之亦然。本病例报告讨论了一名年轻的消瘦男子,他在患有结核病的情况下出现双侧足下垂,后来经COVID-19合并感染确诊,神经传导研究显示为轴索性神经病变。该报告强调了在COVID-19患者中对结核病进行鉴别诊断的重要性,以及在排除营养性原因后,对于患有周围神经病变的患者考虑结核病的必要性。

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A profile of a retrospective cohort of 22 patients with COVID-19 and active/treated tuberculosis.一项关于 22 例 COVID-19 合并活动性/治疗性结核病患者的回顾性队列研究。
Eur Respir J. 2020 Nov 19;56(5). doi: 10.1183/13993003.03408-2020. Print 2020 Nov.
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Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19.既往和活动性肺结核会增加 COVID-19 患者的死亡风险并延长其康复时间。
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Guillain-Barré syndrome associated with SARS-CoV-2 infection. A systematic review.
大流行疫苗接种前时期新冠病毒病和结核病患者的临床结局:一项系统评价
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Clinical Features and Treatment Outcome of Coronavirus and Tuberculosis Co-Infected Patients: A Systematic Review of Case Reports.冠状病毒与结核病合并感染患者的临床特征及治疗结果:病例报告的系统评价
Infect Drug Resist. 2022 Jul 27;15:4037-4046. doi: 10.2147/IDR.S370837. eCollection 2022.
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Global prevalence, treatment and outcome of tuberculosis and COVID-19 coinfection: a systematic review and meta-analysis (from November 2019 to March 2021).全球结核病和 COVID-19 合并感染的患病率、治疗和结局:系统评价和荟萃分析(2019 年 11 月至 2021 年 3 月)。
BMJ Open. 2022 Jun 20;12(6):e059396. doi: 10.1136/bmjopen-2021-059396.
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and SARS-CoV-2 Coinfections: A Review.以及新型冠状病毒2型合并感染:一篇综述。
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