Differences in image-enhanced endoscopic findings between -associated and autoimmune gastritis.

The aim of this study was to elucidate the differences in image-enhanced endoscopy (IEE) findings between - -associated and autoimmune gastritis. Seven -naïve, 21 patients with -associated gastritis and seven with autoimmune gastritis were enrolled. Mucosal atrophy in the corpus was evaluated using autofluorescence imaging and classified into small, medium and large. In a 2 × 2-cm area of the lesser curvature of the lower corpus, micromucosal pattern was evaluated by magnifying narrow band imaging and proportion of foveola (FV)- and groove (GR)-type mucosa was classified into FV > 80 %, FV 50 % to 80 %, GR 50 % to 80 %, and GR > 80 %, then a biopsy specimen was taken. Fifteen of 21 (71 %) -associated gastritis patients exhibited medium-to-large atrophic mucosa at the corpus lesser curvature. All autoimmune gastritis patients had large atrophic mucosa throughout the corpus (  < 0.001). All -naïve patients had the FV > 80 % micromucosal pattern. Nineteen of 21 (90 %) -associated gastritis patients had varying proportions of GR- and FV-type mucosae and five of seven (71 %) autoimmune gastritis patients showed FV > 80 % mucosa (  < 0.001). Compared with patients who were -naïve, patients with -associated and autoimmune gastritis exhibited a higher grade of atrophy (  < 0.001), but only patients with -associated gastritis showed a higher grade of intestinal metaplasia (  = 0.022). Large mucosal atrophy with FV > 80 % micromucosal pattern had sensitivity of 71 % (95 % CI: 29 %-96 %) and specificity of 100 % (95 % CI: 88 % to 100 %) for diagnosis of autoimmune gastritis. IEE findings of the gastric corpus differed between -associated and autoimmune gastritis, suggesting different pathogenesis of the two diseases.