School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
Chem Soc Rev. 2021 Jan 21;50(2):898-944. doi: 10.1039/d0cs00354a. Epub 2021 Jan 6.
While the global market for peptide/protein-based therapeutics is witnessing significant growth, the development of peptide drugs remains challenging due to their low oral bioavailability, poor membrane permeability, and reduced metabolic stability. However, a toolbox of chemical approaches has been explored for peptide modification to overcome these obstacles. In recent years, there has been a revival of interest in photoinduced radical thiol-ene chemistry as a powerful tool for the construction of therapeutic peptides.
尽管基于肽/蛋白质的治疗药物的全球市场正在见证显著的增长，但由于肽类药物的口服生物利用度低、膜通透性差和代谢稳定性降低，其开发仍然具有挑战性。然而，已经探索了一系列化学方法来修饰肽以克服这些障碍。近年来，光诱导自由基硫醇-烯反应作为构建治疗性肽的有力工具重新引起了人们的兴趣。
