Electroanalysis and Bioelectrochemistry Laboratory, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, Republic of China.
Department of Materials, Imperial College London, London, SW7 2AZ, UK.
Mikrochim Acta. 2021 Jan 6;188(1):19. doi: 10.1007/s00604-020-04645-5.
A needle-shaped perovskite, barium stannate (BaSnO), was synthesized via a co-precipitation technique for the simultaneous electrochemical determination of antibiotic drug nitrofurantoin (NFTO) and pericardial drug nifedipine (NFP). The spectroscopic and microscopic result confirms that as-prepared BaSnO particles formed with desired crystalline nature, functional group, pore size, pore diameter, and fine needle-like morphology. The simultaneous electrochemical detection of the two pharmaceutical compounds was examined via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) technique using BaSnO-modified glassy carbon electrode (BaSnO/GCE) at a potential range from +0.4 to - 1.2 V. The discrete and simultaneous detection of NFTO and NFP at the BaSnO sensor exhibits higher catalytic activity in terms of cathodic current and cathodic potential compared to bare GCE. DPV results of the BaSnO sensor provide improved linear ranges and limits of detection for NFTO (0.01-42.65 µM; 42.65-557.65 μM, 0.062 μM, respectively) and NFP (0.01-697.65 μM, 0.0168 μM, respectively). Besides, the BaSnO-fabricated sensor exhibits good sensitivity, reproducibility, and repeatability. The modified electrode shows excellent recoveries of NFTO (97.0-100.7%) and NFP (98.7-101.3%) in plasma, urine, and milk samples with an acceptable relative standard deviation (RSD) of 1.6-4.8%. Graphical abstract Needle-shaped BaSnO perovskite material for simultaneous electrochemical sensing of pharmaceutical drugs.
一种针状钙钛矿材料，氧化钡锡（BaSnO），通过共沉淀技术合成，用于同时电化学测定抗生素药物呋喃妥因（NFTO）和心脏药物硝苯地平（NFP）。光谱和显微镜结果证实，所制备的 BaSnO 颗粒具有所需的结晶性质、官能团、孔径、孔径和细针状形态。通过循环伏安法（CV）和差分脉冲伏安法（DPV）技术，在 BaSnO 修饰的玻碳电极（BaSnO/GCE）上，在 +0.4 至 -1.2 V 的电位范围内，对两种药物化合物的同时电化学检测进行了研究。与裸 GCE 相比，BaSnO 传感器对 NFTO 和 NFP 的离散和同时检测表现出更高的催化活性，体现在阴极电流和阴极电位方面。DPV 结果表明，BaSnO 传感器对 NFTO（0.01-42.65 µM；42.65-557.65 µM，0.062 µM，分别）和 NFP（0.01-697.65 µM，0.0168 µM，分别）具有改进的线性范围和检测限。此外，BaSnO 制造的传感器具有良好的灵敏度、重现性和可重复性。修饰电极在血浆、尿液和牛奶样品中对 NFTO（97.0-100.7%）和 NFP（98.7-101.3%）表现出优异的回收率，相对标准偏差（RSD）为 1.6-4.8%。
摘要 针状 BaSnO 钙钛矿材料用于同时电化学检测药物。
