胃型宫颈腺癌伴鳞状分化：隐匿于腺鳞癌中？
Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?
机构信息
Department of Diagnostic Pathology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Department of Gynecology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
出版信息
Virchows Arch. 2021 Aug;479(2):407-412. doi: 10.1007/s00428-020-02997-0. Epub 2021 Jan 6.
Gastric-type adenocarcinoma (GAS) of the cervix is a human papilloma virus (HPV)-independent, aggressive, and chemo-resistant adenocarcinoma. However, although the histopathological features of GAS have been extensively investigated, squamous differentiation has not been mentioned. This study aimed to elucidate the frequency of GAS with squamous differentiation and describe their clinicopathological characteristics. We retrospectively evaluated 78 patients with GAS (n = 13) and adenosquamous carcinoma (n = 65) diagnosed between 2000 and 2020. Two patients with GAS with squamous differentiation were identified. Both tumors showed advanced stage (pT2bN1) and had predominant GAS and merged squamous cell carcinoma components without p16-block positivity and HPV DNA. Gastric-type adenocarcinoma in situ was confirmed in both cases. Some cases of GAS could show squamous differentiation mimicking the usual, HPV-associated, adenosquamous carcinoma. GAS with squamous differentiation is recognized as an HPV-independent cancer.
宫颈胃型腺癌（GAS）是一种人乳头瘤病毒（HPV）无关的侵袭性、化疗耐药性腺癌。然而，尽管 GAS 的组织病理学特征已经得到广泛研究，但鳞状分化尚未提及。本研究旨在阐明具有鳞状分化的 GAS 的频率，并描述其临床病理特征。我们回顾性评估了 2000 年至 2020 年间诊断的 78 例 GAS（n=13）和腺鳞癌（n=65）患者。发现 2 例 GAS 具有鳞状分化。这两个肿瘤均处于晚期（pT2bN1），主要由 GAS 和合并的鳞状细胞癌组成，无 p16 阻断阳性和 HPV DNA。在这两个病例中均证实存在胃型原位腺癌。一些 GAS 病例可能表现出类似于常见的 HPV 相关腺鳞癌的鳞状分化。具有鳞状分化的 GAS 被认为是一种 HPV 无关的癌症。
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