Sukhareva-Nemakova N N, Terent'eva T G, Uriniuk V M, Silaev A B, Navashin S M
Antibiotiki. 1977 Aug;22(8):727-34.
Water-soluble monoethers of sucrose and fatty acids were obtained from Trypanosoma lewisi and Astasia longa. The maximum tolerated dose of the preparations on their single intraperitoneal administration was more than 25 g/kg. The doses of 10--40 mg/kg were used repeatedly in therapy. Carcinoma 755, Lewis carcinoma, sarcoma 45, sarcoma 37 and sarcoma 180 were sensitive to the preparations. The preparations were inactive against experimental leukemia.
从路氏锥虫和长阿斯塔虫中获得了蔗糖和脂肪酸的水溶性单醚。这些制剂单次腹腔注射的最大耐受剂量超过25克/千克。在治疗中反复使用10 - 40毫克/千克的剂量。755癌、刘易斯癌、45肉瘤、37肉瘤和180肉瘤对这些制剂敏感。这些制剂对实验性白血病无活性。
