Saf'ianova V M, Emel'ianova L P, Sukhareva N N, Uriniuk V M
Antibiotiki. 1978 Nov;23(11):1918-24.
The effect of lipid preparations Nos. 59 and 60 isolated from Protozoa on experimental leishmaniosis of golden hamsters was studied. Preparations Nos. 59 and 60 are water-soluble derivatives of fatty acids isolated from Trypanosoma lewisi and Astasia longa respectively. It was found that both preparations administered to the animals simultaneously with the causative agent or after formation of the leishmaniosis infiltrates inhibited the development of the disease clinical signs. Such an effect of the preparations was observed only during the period of the animals exposure to them. After discontinuation of the treatment the development of the clinical process proceeded the same as in the control animals. The lipid preparation No. 60 differing from preparation No. 59 by high content of C20-poly-unsaturated fatty acids was more active and induced a significant decrease in the size of the leishmaniosis infiltrates formed. Preparation No. 60 was more effective in the treatment of the animals infected with L. tropica major than in the animals infected with L. tropica minor. Preparation No. 59 had no significant effect on multiplication and morphology of the parazites.
研究了从原生动物中分离出的59号和60号脂质制剂对金黄仓鼠实验性利什曼病的影响。59号和60号制剂分别是从路氏锥虫和长眼虫中分离出的脂肪酸的水溶性衍生物。结果发现，这两种制剂在与病原体同时给药或在利什曼病浸润形成后给药时，均能抑制疾病临床症状的发展。制剂的这种作用仅在动物接触它们的期间观察到。停止治疗后，临床病程的发展与对照动物相同。60号脂质制剂与59号制剂不同，其C20多不饱和脂肪酸含量高，活性更强，能使形成的利什曼病浸润灶大小显著减小。60号制剂对感染大型热带利什曼原虫的动物的治疗效果比对感染小型热带利什曼原虫的动物更有效。59号制剂对寄生虫的增殖和形态没有显著影响。
