Statistics Division, McGlennon MotiMetrics, Maiden Rock, WI, USA.
Division of Scientific Research Writing, Medwrite, Maiden Rock, WI, USA.
Obes Surg. 2021 Jan;31(1):26-35. doi: 10.1007/s11695-020-05142-7. Epub 2021 Jan 6.
Obesity is a common outcome of traumatic brain injury (TBI) that exacerbates principal TBI symptom domains identified as common areas of post-TBI long-term dysfunction. Obesity is also associated with increased risk of later-life dementia and Alzheimer's disease. Patients with obesity and chronic TBI may be more vulnerable to long-term mental abnormalities. This review explores the question of whether weight loss induced by bariatric surgery could delay or perhaps even reverse the progression of mental deterioration. Bariatric surgery, with its induction of weight loss, remission of type 2 diabetes, and other expressions of the metabolic syndrome, improves metabolic efficiency, leads to reversal of brain lesions seen on imaging studies, and improves function. These observations suggest that metabolic/bariatric surgery may be the most effective therapy for TBI.
肥胖是创伤性脑损伤 (TBI) 的常见后果，会加剧 TBI 主要症状领域，这些领域被确定为 post-TBI 长期功能障碍的常见领域。肥胖也与晚年痴呆症和阿尔茨海默病的风险增加有关。肥胖和慢性 TBI 的患者可能更容易出现长期精神异常。本综述探讨了减重手术引起的体重减轻是否可以延迟甚至可能逆转精神恶化的进展。减重手术通过诱导体重减轻、2 型糖尿病缓解和代谢综合征的其他表现，提高了代谢效率，导致影像学研究中观察到的脑损伤逆转，并改善了功能。这些观察结果表明，代谢/减重手术可能是 TBI 最有效的治疗方法。
