Department of Digestive and Minimally Invasive Surgery, Saint-Germain-en-Laye Medical Center, Poissy, France.
Saint Georges Hospital University Medical Center, University of Balamand, Beirut, Lebanon.
Obes Surg. 2018 Jul;28(7):2069-2077. doi: 10.1007/s11695-018-3252-6.
Bariatric surgery is used to induce weight loss (baros = weight). Evidence has shown that bariatric surgery improves the comorbid conditions associated with obesity such as hypertension, hyperlipidemia, and type 2 diabetes mellitus T2DM. Hence, shifting towards using metabolic surgery instead of bariatric surgery is currently more appropriate in certain subset of patients. Endocrine changes resulting from operative manipulation of the gastrointestinal tract after metabolic surgery translate into metabolic benefits with respect to the comorbid conditions. Other changes include bacterial flora rearrangement, bile acids secretion, and adipose tissue effect. The aim of this systematic review is to examine clinical trials regarding long-term effects of bariatric and metabolic surgery on patients with T2DM and to evaluate the potential mechanisms leading to the improvement in the glycaemic control.
减重手术用于诱导体重减轻（baros = 体重）。有证据表明，减重手术可改善与肥胖相关的合并症，如高血压、高血脂和 2 型糖尿病 T2DM。因此，目前对于某些特定患者群体，采用代谢手术替代减重手术更为合适。代谢手术后胃肠道手术操作引起的内分泌变化转化为与合并症相关的代谢益处。其他变化包括细菌菌群重排、胆酸分泌和脂肪组织效应。本系统评价的目的是研究关于减重和代谢手术对 T2DM 患者长期影响的临床试验，并评估导致血糖控制改善的潜在机制。
