• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
CD of six different conformational rearrangements of poly[d(A-G).d(C-T)] induced by low pH.低pH诱导的聚[d(A-G).d(C-T)]六种不同构象重排的圆二色光谱
Nucleic Acids Res. 1988 Jan 25;16(2):719-38. doi: 10.1093/nar/16.2.719.
2
CD evidence that the alternating purine-pyrimidine sequence poly[d(A-C).d(G-T)], but not poly[d(A-T).d(A-T)], undergoes an acid-induced transition to a modified secondary conformation.有证据表明，嘌呤 - 嘧啶交替序列聚[d(A - C).d(G - T)]，而非聚[d(A - T).d(A - T)]，会发生酸诱导的转变，形成一种修饰的二级构象。
Nucleic Acids Res. 1990 Jul 25;18(14):4111-22. doi: 10.1093/nar/18.14.4111.
3
Circular dichroism of two conformations of poly[d(G-C)] induced by low pH.低pH诱导的聚[d（G-C）]两种构象的圆二色性
Nucleic Acids Res. 1986 Dec 22;14(24):10091-112. doi: 10.1093/nar/14.24.10091.
4
Nature of conformational changes in poly[d(A-T)-d(A-T)] in the premelting region.聚[d（A-T）-d（A-T）]在预熔解区域构象变化的本质。
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3453-7. doi: 10.1073/pnas.73.10.3453.
5
Complexes formed by (pyrimidine)n . (purine)n DNAs on lowering the pH are three-stranded.（嘧啶）n.（嘌呤）n DNA在降低pH值时形成的复合物是三链的。
Nucleic Acids Res. 1979 Jul 11;6(9):3073-91. doi: 10.1093/nar/6.9.3073.
6
Spectroscopic and calorimetric investigation on the DNA triplex formed by d(CTCTTCTTTCTTTTCTTTCTTCTC) and d(GAGAAGAAAGA) at acidic pH.在酸性pH条件下，对由d(CTCTTCTTTCTTTTCTTTCTTCTC)和d(GAGAAGAAAGA)形成的DNA三链体进行光谱和量热研究。
Nucleic Acids Res. 1990 Jun 25;18(12):3557-64. doi: 10.1093/nar/18.12.3557.
7
Proton NMR and optical spectroscopic studies on the DNA triplex formed by d-A-(G-A)7-G and d-C-(T-C)7-T.对由d-A-(G-A)7-G和d-C-(T-C)7-T形成的DNA三链体进行的质子核磁共振和光谱学研究。
J Biomol Struct Dyn. 1991 Apr;8(5):911-33. doi: 10.1080/07391102.1991.10507857.
8
Mercury-induced transitions between right-handed and putative left-handed forms of poly[d(A-T).d(A-T)] and poly[d(G-C).d(G-C)].汞诱导的聚[d(A-T).d(A-T)]和聚[d(G-C).d(G-C)]从右手形式到假定左手形式的转变。
Nucleic Acids Res. 1989 Nov 25;17(22):9075-86. doi: 10.1093/nar/17.22.9075.
9
Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study.DNA三链体稳定性及熔解行为的热力学表征：一项光谱与量热研究
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9436-40. doi: 10.1073/pnas.87.23.9436.
10
Z form of poly d(A-T).poly d(A-T) in solution studied by CD and UV spectroscopies.通过圆二色光谱和紫外光谱研究溶液中聚d（A-T）·聚d（A-T）的Z型结构。
J Biomol Struct Dyn. 1987 Aug;5(1):97-104. doi: 10.1080/07391102.1987.10506378.

引用本文的文献

1
Revealing structural peculiarities of homopurine GA repetition stuck by i-motif clip.揭示 i-motif 夹子卡住的同嘌呤 GA 重复序列的结构特征。
Nucleic Acids Res. 2021 Nov 18;49(20):11425-11437. doi: 10.1093/nar/gkab915.
2
Evidence from CD spectra that d(purine).r(pyrimidine) and r(purine).d(pyrimidine) hybrids are in different structural classes.圆二色光谱的证据表明，d（嘌呤）.r（嘧啶）和r（嘌呤）.d（嘧啶）杂交体属于不同的结构类别。
Nucleic Acids Res. 1994 Oct 11;22(20):4326-34. doi: 10.1093/nar/22.20.4326.
3
Structural polymorphism of homopurine--homopyrimidine sequences: the secondary DNA structure adopted by a d(GA.CT)22 sequence in the presence of zinc ions.同嘌呤-同嘧啶序列的结构多态性：锌离子存在时d(GA.CT)22序列所采用的二级DNA结构
EMBO J. 1989 Jul;8(7):2087-94. doi: 10.1002/j.1460-2075.1989.tb03617.x.
4
CD evidence that the alternating purine-pyrimidine sequence poly[d(A-C).d(G-T)], but not poly[d(A-T).d(A-T)], undergoes an acid-induced transition to a modified secondary conformation.有证据表明，嘌呤 - 嘧啶交替序列聚[d(A - C).d(G - T)]，而非聚[d(A - T).d(A - T)]，会发生酸诱导的转变，形成一种修饰的二级构象。
Nucleic Acids Res. 1990 Jul 25;18(14):4111-22. doi: 10.1093/nar/18.14.4111.
5
DNA-sequence and metal-ion specificity of the formation of *H-DNA.H-DNA形成的DNA序列和金属离子特异性。
Nucleic Acids Res. 1990 Jul 25;18(14):4067-73. doi: 10.1093/nar/18.14.4067.
6
Nucleotide sequence and nuclear protein binding of the two regulatory sequences upstream of the am (GDH) gene in Neurospora.粗糙脉孢菌中am（GDH）基因上游两个调控序列的核苷酸序列及核蛋白结合情况
Mol Gen Genet. 1990 Apr;221(2):148-54. doi: 10.1007/BF00261714.
7
Vacuum UV CD spectra of homopolymer duplexes and triplexes containing A.T or A.U base pairs.含有A.T或A.U碱基对的均聚物双链体和三链体的真空紫外圆二色光谱。
Nucleic Acids Res. 1991 May 11;19(9):2275-80. doi: 10.1093/nar/19.9.2275.
8
Mung bean nuclease cleavage pattern at a polypurine.polypyrimidine sequence upstream from the mouse metallothionein-I gene.绿豆核酸酶在小鼠金属硫蛋白-I基因上游多聚嘌呤-多聚嘧啶序列处的切割模式。
Nucleic Acids Res. 1991 Apr 11;19(7):1639-47. doi: 10.1093/nar/19.7.1639.
9
Identification of novel single-stranded d(TC)n binding proteins in several mammalian species.
Nucleic Acids Res. 1991 Feb 25;19(4):949-53. doi: 10.1093/nar/19.4.949.
10
Single-stranded nucleic acid helical secondary structure stabilized by ionic bonds: d(A(+)-G)10.通过离子键稳定的单链核酸螺旋二级结构：d(A(+)-G)10
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9242-6. doi: 10.1073/pnas.89.19.9242.

本文引用的文献

1
Polymorphism of DNA double helices.DNA双螺旋的多态性
J Mol Biol. 1980 Oct 15;143(1):49-72. doi: 10.1016/0022-2836(80)90124-2.
2
Circular dichroism spectra show that repeating dinucleotide DNAs may form helices in which every other base is looped out.圆二色光谱表明，重复二核苷酸DNA可能形成螺旋结构，其中每隔一个碱基就会形成环状突出。
Nucleic Acids Res. 1980 Aug 25;8(16):3695-707. doi: 10.1093/nar/8.16.3695.
3
Poly(pyrimidine) . poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH.含有5-甲基胞嘧啶的聚（嘧啶）·聚（嘌呤）合成DNA在中性pH下形成稳定的三链体。
Nucleic Acids Res. 1984 Aug 24;12(16):6603-14. doi: 10.1093/nar/12.16.6603.
4
Anatomy of hypersensitive sites.过敏位点的解剖结构。
Nature. 1984;309(5965):213-4. doi: 10.1038/309213a0.
5
Polypurine DNAs and RNAs form secondary structures which may be tetra-stranded.多嘌呤DNA和RNA形成的二级结构可能是四链的。
Nucleic Acids Res. 1980 Sep 25;8(18):4305-20. doi: 10.1093/nar/8.18.4305.
6
Possible structures of homopurine-homopyrimidine S1-hypersensitive sites.同嘌呤-同嘧啶S1超敏位点的可能结构。
Nucleic Acids Res. 1984 Nov 12;12(21):8059-72. doi: 10.1093/nar/12.21.8059.
7
Physicochemical studies on polydeoxyribonucleotides containing defined repeating nucleotide sequences.对含有特定重复核苷酸序列的聚脱氧核糖核苷酸的物理化学研究。
J Mol Biol. 1970 Dec 28;54(3):465-97. doi: 10.1016/0022-2836(70)90121-x.
8
Photochemical demonstration of stacked C.C+ base pairs in a novel DNA secondary structure.在一种新型DNA二级结构中堆积的C.C+碱基对的光化学证明。
Biochemistry. 1985 Mar 26;24(7):1676-83. doi: 10.1021/bi00328a016.
9
A pH-dependent structural transition in the homopurine-homopyrimidine tract in superhelical DNA.超螺旋DNA中同型嘌呤-同型嘧啶序列的pH依赖性结构转变。
J Biomol Struct Dyn. 1985 Oct;3(2):327-38. doi: 10.1080/07391102.1985.10508420.
10
Structures of homopurine-homopyrimidine tract in superhelical DNA.超螺旋DNA中同嘌呤-同嘧啶序列的结构
J Biomol Struct Dyn. 1986 Feb;3(4):667-9. doi: 10.1080/07391102.1986.10508454.

低pH诱导的聚[d(A-G).d(C-T)]六种不同构象重排的圆二色光谱

CD of six different conformational rearrangements of poly[d(A-G).d(C-T)] induced by low pH.

作者信息

Antao V P, Gray D M, Ratliff R L

机构信息

Program in Molecular and Cell Biology, University of Texas, Dallas, Richardson 75083-0688.

出版信息

Nucleic Acids Res. 1988 Jan 25;16(2):719-38. doi: 10.1093/nar/16.2.719.

DOI:10.1093/nar/16.2.719
PMID:3340552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC334687/
Abstract

On the basis of circular dichroism (CD) data, we have now identified six different conformational states (other than the duplex) of poly[d(A-G).d(C-T)] at pH values between 8 and 2.5 (at 0.01M Na+; 20 degrees C). Three of these structural rearrangements were observed as the pH was lowered from 8 to 2.5, and three additional rearrangements were observed as the pH was raised from 2.5 back to neutral pH. The major components of the six conformational states were defined using appropriate combinations of the CD spectra of the duplex, triplex, and denatured forms of this polymer, as well as the CD spectra of the individual single strands and their respective acid-induced self-complexes. Our results show that the acid-induced rearrangements of poly[d(A-G).d(C-T)] include not only the poly[d(C+-T).d(A-G).d(C-T)] triplex, but also include the poly[d(C-T)] loop-out structure and a self-complexed form of the poly[d(A-G)] strand that is pH-dependent.

摘要

基于圆二色性（CD）数据，我们现已确定了聚[d（A-G）.d（C-T）]在pH值介于8至2.5之间（0.01M Na⁺；20℃）时的六种不同构象状态（双链体除外）。随着pH值从8降至2.5，观察到其中三种结构重排；随着pH值从2.5升至中性pH值，又观察到另外三种重排。使用该聚合物双链体、三链体和变性形式的CD光谱的适当组合，以及各个单链及其各自酸诱导的自复合物的CD光谱，定义了六种构象状态的主要成分。我们的结果表明，聚[d（A-G）.d（C-T）]的酸诱导重排不仅包括聚[d（C⁺-T）.d（A-G）.d（C-T）]三链体，还包括聚[d（C-T）]环出结构以及pH依赖性的聚[d（A-G）]链的自复合形式。