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1
CD evidence that the alternating purine-pyrimidine sequence poly[d(A-C).d(G-T)], but not poly[d(A-T).d(A-T)], undergoes an acid-induced transition to a modified secondary conformation.有证据表明，嘌呤 - 嘧啶交替序列聚[d(A - C).d(G - T)]，而非聚[d(A - T).d(A - T)]，会发生酸诱导的转变，形成一种修饰的二级构象。
Nucleic Acids Res. 1990 Jul 25;18(14):4111-22. doi: 10.1093/nar/18.14.4111.
2
CD of six different conformational rearrangements of poly[d(A-G).d(C-T)] induced by low pH.低pH诱导的聚[d(A-G).d(C-T)]六种不同构象重排的圆二色光谱
Nucleic Acids Res. 1988 Jan 25;16(2):719-38. doi: 10.1093/nar/16.2.719.
3
Circular dichroism of two conformations of poly[d(G-C)] induced by low pH.低pH诱导的聚[d（G-C）]两种构象的圆二色性
Nucleic Acids Res. 1986 Dec 22;14(24):10091-112. doi: 10.1093/nar/14.24.10091.
4
fd gene 5 protein binds to double-stranded polydeoxyribonucleotides poly(dA.dT) and poly[d(A-T).d(A-T)].fd基因5蛋白与双链多脱氧核糖核苷酸聚（dA.dT）和聚[d（A-T）.d（A-T）]结合。
Biochemistry. 1987 Nov 17;26(23):7210-4. doi: 10.1021/bi00397a002.
5
Z form of poly d(A-T).poly d(A-T) in solution studied by CD and UV spectroscopies.通过圆二色光谱和紫外光谱研究溶液中聚d（A-T）·聚d（A-T）的Z型结构。
J Biomol Struct Dyn. 1987 Aug;5(1):97-104. doi: 10.1080/07391102.1987.10506378.
6
Stabilization of Double Stranded Homologous Poly(dA)·Poly(dT) by Taxol.紫杉醇对双链同源聚（dA）·聚（dT）的稳定作用
J Biomol Struct Dyn. 2000;17 Suppl 1:349-54. doi: 10.1080/07391102.2000.10506640.
7
Conformational transitions of alternating purine-pyrimidine DNAs in perchlorate ethanol solutions.高氯酸盐乙醇溶液中交替嘌呤-嘧啶DNA的构象转变
Biophys J. 1995 Nov;69(5):2033-43. doi: 10.1016/S0006-3495(95)80073-1.
8
Parallel-stranded duplex DNA containing blocks of trans purine-purine and purine-pyrimidine base pairs.含有反式嘌呤-嘌呤和嘌呤-嘧啶碱基对片段的平行链双链DNA。
Nucleic Acids Res. 1994 Aug 25;22(16):3293-303. doi: 10.1093/nar/22.16.3293.
9
Nature of conformational changes in poly[d(A-T)-d(A-T)] in the premelting region.聚[d（A-T）-d（A-T）]在预熔解区域构象变化的本质。
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3453-7. doi: 10.1073/pnas.73.10.3453.
10
Energetics of Z-DNA formation in poly d(A-T), poly d(G-C), and poly d(A-C) poly d(G-T).聚d(A-T)、聚d(G-C)和聚d(A-C)·聚d(G-T)中Z-DNA形成的能量学
Nucleic Acids Res. 1993 May 25;21(10):2343-8. doi: 10.1093/nar/21.10.2343.

本文引用的文献

1
Circular dichroism spectra show that repeating dinucleotide DNAs may form helices in which every other base is looped out.圆二色光谱表明，重复二核苷酸DNA可能形成螺旋结构，其中每隔一个碱基就会形成环状突出。
Nucleic Acids Res. 1980 Aug 25;8(16):3695-707. doi: 10.1093/nar/8.16.3695.
2
The pH-dependent structure of calf thymus DNA studied by Raman spectroscopy.通过拉曼光谱研究小牛胸腺DNA的pH依赖性结构。
Biophys Chem. 1982 Apr;15(1):53-64. doi: 10.1016/0301-4622(82)87016-6.
3
Conformational transitions of poly(dA-dC).poly(dG-dT) induced by high salt or in ethanolic solution.高盐或乙醇溶液诱导的聚（dA-dC）·聚（dG-dT）的构象转变
Nucleic Acids Res. 1982 Feb 11;10(3):1081-91. doi: 10.1093/nar/10.3.1081.
4
A Z-like form of poly(dA-dC).poly(dG-dT) in solution?溶液中聚（dA-dC）·聚（dG-dT）的Z型结构？
Nucleic Acids Res. 1982 Feb 11;10(3):1071-80. doi: 10.1093/nar/10.3.1071.
5
Left-handed helical conformation of poly[d(A-m5C).d(G-T)].聚[d(A-5-甲基胞嘧啶).d(G-T)]的左手螺旋构象
Nature. 1983;304(5921):83-6. doi: 10.1038/304083a0.
6
Facile transition of poly[d(TG) x d(CA)] into a left-handed helix in physiological conditions.在生理条件下，聚[d(TG)x d(CA)]能轻松转变为左手螺旋。
Nature. 1983 Apr 14;302(5909):632-4. doi: 10.1038/302632a0.
7
A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.一种具有形成Z-DNA潜力的新型重复元件广泛存在于进化上多样的真核生物基因组中。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6465-9. doi: 10.1073/pnas.79.21.6465.
8
Formation of psi (+) and psi (-) DNA.ψ（+）和ψ（-）DNA的形成。
Biopolymers. 1984 Feb;23(2):325-35. doi: 10.1002/bip.360230211.
9
The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.序列（dC-dA）n×（dG-dT）n在负超螺旋质粒中形成左手Z-DNA。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1821-5. doi: 10.1073/pnas.80.7.1821.
10
Circular dichroism measurements show that C.C+ base pairs can coexist with A.T base pairs between antiparallel strands of an oligodeoxynucleotide double-helix.圆二色性测量表明，在寡脱氧核苷酸双螺旋的反平行链之间，C.C⁺碱基对可以与A.T碱基对共存。
Nucleic Acids Res. 1984 Oct 11;12(19):7565-80. doi: 10.1093/nar/12.19.7565.

有证据表明，嘌呤 - 嘧啶交替序列聚[d(A - C).d(G - T)]，而非聚[d(A - T).d(A - T)]，会发生酸诱导的转变，形成一种修饰的二级构象。

CD evidence that the alternating purine-pyrimidine sequence poly[d(A-C).d(G-T)], but not poly[d(A-T).d(A-T)], undergoes an acid-induced transition to a modified secondary conformation.

作者信息

Antao V P, Ratliff R L, Gray D M

机构信息

Program in Molecular and Cell Biology, University of Texas at Dallas, Richardson 75083-0688.

出版信息

Nucleic Acids Res. 1990 Jul 25;18(14):4111-22. doi: 10.1093/nar/18.14.4111.

DOI:10.1093/nar/18.14.4111
PMID:2377455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC331167/
Abstract

Circular dichroism and UV absorption data showed that poly[d(A-C).d(G-T)] (at 0.01M Na+ (phosphate), 20 degrees C) underwent two reversible conformational transitions upon lowering of the pH. The first transition was complete at about pH 3.9 and resulted in an acid form of the polymer that was most likely a modified, protonated duplex. The second transition occurred between pH 3.9 and 3.4 and consisted of the denaturation of this protonated duplex to the single strands. UV absorption and CD data also showed that the separated poly[d(A-C)] strand formed two acid-induced self-complexes with pKa values of 6.1 and 4.7 (at 0.01M Na+). However, neither one of these poly[d(A-C)] self-complexes was part of the acid-induced rearrangements of the duplex poly[d(A-C).d(G-T)]. Acid titration of the separated poly[d(G-T)] strand, under similar conditions, did not show the formation of any protonated poly[d(G-T)] self-complexes. In contrast to poly[d(A-C).d(G-T)], poly[d(A-T).d(A-T)] underwent only one acid-induced transition, which consisted of the denaturation of the duplex to the single strands, as the pH was lowered from 7 to 3.

摘要

圆二色性和紫外吸收数据表明，聚[d(A-C).d(G-T)]（在0.01M Na⁺（磷酸盐），20℃条件下）在pH降低时经历了两个可逆的构象转变。第一个转变在约pH 3.9时完成，产生了聚合物的一种酸性形式，最有可能是一种修饰的、质子化的双链体。第二个转变发生在pH 3.9和3.4之间，由这种质子化双链体变性为单链组成。紫外吸收和圆二色性数据还表明，分离出的聚[d(A-C)]链形成了两个酸诱导的自复合物，其pKa值分别为6.1和4.7（在0.01M Na⁺条件下）。然而，这些聚[d(A-C)]自复合物都不是双链体聚[d(A-C).d(G-T)]酸诱导重排的一部分。在类似条件下，对分离出的聚[d(G-T)]链进行酸滴定，未显示形成任何质子化的聚[d(G-T)]自复合物。与聚[d(A-C).d(G-T)]不同，聚[d(A-T).d(A-T)]在pH从7降至3时仅经历了一个酸诱导的转变，即双链体变性为单链。