Li Li, Li Qingling, Zhao Mengli, Dong Lei, Wu Jie, Li Dejun
College of Physics and Materials Science and Tianjin International Joint Research Center of Surface Technology for Energy Storage Materials, Tianjin Normal University, Tianjin 300387, China.
ACS Biomater Sci Eng. 2019 Jul 8;5(7):3303-3310. doi: 10.1021/acsbiomaterials.9b00248. Epub 2019 Jun 24.
Titanium alloy (Ti-6Al-4 V) has good biocompatibility and mechanical properties, but its biologically inert and poor antibacterial property limit its application in the field of medical implants. In this study, titanium nitride (TiN) is first deposited on the surface of titanium alloy to wrap toxic elements (for example, vanadium). Then Zn and Ag ions with different ratios are simultaneously implanted into TiN via a plasma immersion ion implantation (PIII) system. X-ray photoelectron spectrometer proves the presence of Zn, Ag, and TiN on the surface of Zn/Ag-TiN. Protein adsorption suggests that, with the increase of Zn ratio, the adsorption ability is enhanced. Biological assays indicate that Zn/Ag(1/0.3)-TiN has the best cell proliferation and adhesion, because it has a larger ratio of Zn. Zn/Ag(1/2)-TiN has the best antibacterial effect and followed by Zn/Ag(1/0.3)-TiN, since Ag plays a major role in antibacterial activity and Zn is auxiliary. But a large ratio of Ag not only impairs cells but also has a negative effect on antibacterial activity. In conclusion, Zn/Ag(1/0.3)-TiN offers both excellent cytocompatibility and antibacterial activity and has great potential in orthopedic implants.
钛合金（Ti-6Al-4V）具有良好的生物相容性和机械性能，但其生物惰性和较差的抗菌性能限制了其在医用植入物领域的应用。在本研究中，首先在钛合金表面沉积氮化钛（TiN）以包裹有毒元素（例如钒）。然后通过等离子体浸没离子注入（PIII）系统将不同比例的锌和银离子同时注入TiN中。X射线光电子能谱证明了Zn/Ag-TiN表面存在锌、银和TiN。蛋白质吸附表明，随着锌比例的增加，吸附能力增强。生物学分析表明，Zn/Ag(1/0.3)-TiN具有最佳的细胞增殖和黏附能力，因为其锌比例更大。Zn/Ag(1/2)-TiN具有最佳的抗菌效果，其次是Zn/Ag(1/0.3)-TiN，因为银在抗菌活性中起主要作用，锌起辅助作用。但银比例过高不仅会损害细胞，还会对抗菌活性产生负面影响。总之，Zn/Ag(1/0.3)-TiN兼具优异的细胞相容性和抗菌活性，在骨科植入物方面具有巨大潜力。
