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基于整合分析的 在肝细胞癌中的临床价值及潜在机制。

Clinical value and potential mechanisms of in hepatocellular carcinoma based on integrated analysis.

机构信息

Program & Department of Clinical Laboratory Medicine, Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Department of Clinical Laboratory, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

出版信息

Epigenomics. 2021 Feb;13(4):299-317. doi: 10.2217/epi-2020-0363. Epub 2021 Jan 7.

Abstract

This study aimed to unveil the functional roles of in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. was upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve further revealed its prognostic and diagnostic roles. Exploration of the mechanism showed that might exert a pro-cancer role via the lncRNA-miRNA-mRNA network. Our study reveals that upregulated can serve as a potential diagnostic and prognostic biomarker and provides novel clues as to the role of in HCC.

摘要

本研究旨在揭示 在肝细胞癌(HCC)中的功能作用。分别使用发现队列和验证队列来鉴定和验证 在 HCC 中的临床价值。进行了生物信息学分析以探索其潜在机制。 在 HCC 组织和血清样本中上调。生存分析和接收者操作特征曲线进一步揭示了其预后和诊断作用。机制探索表明, 可能通过 lncRNA-miRNA-mRNA 网络发挥致癌作用。我们的研究表明,上调的 可以作为潜在的诊断和预后生物标志物,并为 在 HCC 中的作用提供了新的线索。

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