肝细胞癌中上调的临床价值及潜在机制

Clinical Value and Underlying Mechanisms of Upregulated in Hepatocellular Carcinoma.

作者信息

Zhu Xinyu, Feng Yanlin, He Dingdong, Wang Zi, Huang Fangfang, Tu Jiancheng

机构信息

Department of Laboratory Medicine, Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.

出版信息

Front Oncol. 2021 Jul 5;11:654424. doi: 10.3389/fonc.2021.654424. eCollection 2021.

AIMS

This study aimed to reveal the functional role of in hepatocellular carcinoma (HCC).

MATERIALS & METHODS: 210 serum samples from Zhongnan Hospital of Wuhan University were employed to evaluate clinical value of . Bioinformatics analysis was adopted to explore its potential mechanisms.

RESULTS

was confirmed to be upregulated in HCC tissues and serum samples. Survival analysis and receiver operating characteristic curve revealed its prognostic and diagnostic roles. The combination of serum with AFP can remarkably improve diagnostic ability of HCC. Exploration of the underlying mechanism demonstrated that might exert pro-oncogenic activity by -three miRNAs-four mRNAs network.

CONCLUSIONS

Our study unveiled that upregulated could act as a potential diagnostic and prognostic biomarker and provide a novel insight into the molecular mechanisms of in HCC pathogenesis.