在中国一个大型多民族青年队列中 HEV 的流行情况及潜在危险因素。
HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China.
机构信息
Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
出版信息
Virol J. 2021 Jan 6;18(1):3. doi: 10.1186/s12985-020-01470-3.
BACKGROUND
This cohort study was designed to investigate the prevalence of and potential risk factors of HEV infection in a large multi-ethnic youth cohort in China.
METHODS
Blood samples were collected from participants (n = 6269) and serum was isolated. All serum samples were tested for anti-HEV IgG, anti-HEV IgM antibodies using commercial enzyme immunoassay kits (Wantai Biological Pharmacy Enterprise, Beijing, China).
RESULTS
The overall rate of anti-HEV IgG and anti-HEV IgM prevalence was 4.78% and 0.14%, 0.03% were positive for both anti-HEV IgG and anti-HEV IgM antibodies. Anti-HEV IgG positivity is significantly higher in females (5.27%) compared to males (4.14%) (P = 0.028). Anti-HEV IgG prevalence is significantly (P = 0.0001) higher in Dong (17.57%), Miao (12.23%), Yi (11.04%), Gelao (9.76%), and Bai (10.00%) compared to other ethnic groups. It is significantly higher in Guizhou (11.4%), Sichuan (10.1%), Yunnan (9.3%), and Guangxi (6.9%) than that other province. We found that ethnicity and provincial background are significantly associated with HEV infection in this cohort.
CONCLUSION
This study provides comprehensive information on HEV prevalence in multi-ethnic populations in China. However, our study only focused on a youth population from different provinces of China. Future studies are recommended to investigate HEV prevalence in other age groups of the ethnic populations.
背景
本队列研究旨在调查中国一个大型多民族青年队列中戊型肝炎病毒（HEV）感染的流行率和潜在危险因素。
方法
采集参与者（n=6269）的血样并分离血清。使用商业酶免疫试剂盒（北京万泰生物药业股份有限公司）检测所有血清样本的抗-HEV IgG 和抗-HEV IgM 抗体。
结果
抗-HEV IgG 和抗-HEV IgM 的总流行率分别为 4.78%和 0.14%，同时对两种抗体均呈阳性的比例为 0.03%。女性（5.27%）的抗-HEV IgG 阳性率明显高于男性（4.14%）（P=0.028）。与其他民族相比，侗族（17.57%）、苗族（12.23%）、彝族（11.04%）、仡佬族（9.76%）和白族（10.00%）的抗-HEV IgG 流行率明显更高（P=0.0001）。与其他省份相比，贵州（11.4%）、四川（10.1%）、云南（9.3%）和广西（6.9%）的抗-HEV IgG 流行率明显更高。我们发现，在本队列中，民族和省级背景与 HEV 感染显著相关。
结论
本研究提供了中国多民族人群中 HEV 流行率的全面信息。然而，我们的研究仅关注了来自中国不同省份的青年人群。建议未来的研究调查其他民族年龄组的 HEV 流行率。
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