Comparison of Diagnostic Efficacy Between Contrast-Enhanced Ultrasound and DCE-MRI for Mass- and Non-Mass-Like Enhancement Types in Breast Lesions.

BACKGROUND

Contrast-enhanced ultrasound (CEUS) can provide angiogenesis information about breast lesions; however, its diagnostic performance in comparison with that of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has not been systematically investigated. This study aimed to evaluate the diagnostic efficacy of CEUS and DCE-MRI in mass-like and non-mass-like enhancement types of breast lesions.

MATERIAL AND METHODS

A retrospective study was conducted on 252 patients with breast lesions who underwent CEUS and DCE-MRI before surgery between January 2016 and February 2020. Histopathological results were used as reference standards. All patients were classified into mass-like and non-mass-like enhancement lesion groups. The mass-like lesion group was further divided into three categories according to different sizes (group 1: <10 mm, group 2: 10-20 mm, and group 3: >20 mm). Sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic curve were analyzed to assess the diagnostic performance of these two modalities.

RESULTS

For mass-like breast lesions, DCE-MRI (=0.981) manifested better diagnostic performance than CEUS (=0.940) in medium-sized (10-20 mm) tumors (=2.018, =0.043), but both had similar diagnostic performance in smaller (<10 mm) and larger (>20 mm) tumors (=0.717, =0.394). For non-mass-like enhancement lesions, CEUS and DCE-MRI showed no significant difference (=1.590, =0.119) and revealed good diagnostic performance (=0.859, =0.947) in differentiating the two groups.

CONCLUSION

For mass-like breast lesions, DCE-MRI showed better diagnostic performance than CEUS in differentiating benign and malignant tumors of medium-sizes (10-20mm) but not of smaller (<10mm) and larger (>20 mm) sizes. For non-mass-like lesions, both modalities showed similar diagnostic performance.