类淋巴系统功能障碍可能与正常衰老大脑中的铁沉积有关。
Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain.
作者信息
Zhou Wei, Shen Bo, Shen Wei-Qiang, Chen Hao, Zheng Yi-Feng, Fei Jing-Jing
机构信息
Department of Radiology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China.
Department of Internal Medicine, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China.
出版信息
Front Aging Neurosci. 2020 Dec 21;12:559603. doi: 10.3389/fnagi.2020.559603. eCollection 2020.
The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain. We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship. The mean age of participants was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all < 0.001). The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system. We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.
该研究旨在检测正常衰老大脑中铁沉积与类淋巴系统功能之间的潜在关系。我们招募了213名健康参与者。我们使用沿血管周围间隙扩散率指数（ALPS指数）评估类淋巴系统的功能，通过定量磁化率成像（QSM）评估铁沉积情况，并分析它们之间的关系。参与者的平均年龄为60.1±7.3岁，其中107名（50.2%）为女性。平均ALPS指数为1.4±0.2。尾状核、壳核、苍白球、丘脑、红核、黑质和齿状核的QSM值均与ALPS指数相关（均P<0.001）。本研究的主要发现是，脑区铁沉积与类淋巴系统功能相关。我们首次评估了脑铁沉积与类淋巴系统功能障碍之间的关系。
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